Evidence map›Paper›PMID 40879168›Full record

ArticleOtolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery2026

In Vivo Effects of N,N-Diethyl-Meta-Toluamide (DEET) Exposure on Sinonasal Epithelia in a Murine Model.

Jivianne T Lee, Melodyanne Y Cheng, Eri S Srivatsan, Neda A Moatamed, Saroj K Basak

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In one paragraph

Article in Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jivianne T LeeDepartment of Head and Neck Surgery, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.
Melodyanne Y ChengDavid Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.ORCID https://orcid.org/0000-0002-7081-1517
Eri S SrivatsanDepartment of Surgery, Greater Los Angeles Veterans Administration Healthcare System, Los Angeles, California, USA.
Neda A MoatamedDepartment of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.
Saroj K BasakDepartment of Surgery, Greater Los Angeles Veterans Administration Healthcare System, Los Angeles, California, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Environmental factors, including airborne toxicants, are thought to contribute to the pathogenesis of chronic rhinosinusitis, although the exact mechanism is not fully understood. The purpose of this pilot study is to assess the impact of pesticide, N,N-diethyl-meta-toluamide (DEET), on the sinonasal epithelium using an in vivo murine model. Sixteen mice were exposed for a 2-week period to intranasal solutions containing either saline/50% dimethylsulfoxide (controls, n = 4) or two different concentrations of DEET (0.6 mg: n = 6, 1.0 mg: n = 6). Sinonasal tissue was harvested after the exposure period, and histopathologic analysis was performed. Eleven of the 12 DEET-exposed mice demonstrated inflammatory changes, including increased mucinous cells in the stroma, mucus extravasation, and inflammatory cell infiltrates. All four control mice showed normal respiratory epithelia with no evidence of inflammation. These findings suggest that short-term DEET exposure has pro-inflammatory effects on sinonasal epithelia in an in vivo murine model.

Indexed as

DEETNasal MucosaAnimalsDisease Models, AnimalMicePilot ProjectsRhinitisDEETchronic rhinosinusitisDEETin vivomurine modelpesticides

Identifiers

PMID40879168
PMCPMC13035012

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.