ArticleMovement disorders clinical practice2025
Analysis of DBS Outcome by MDS-UPDRS Severity Levels: Comparison with Changes on MDS-UPDRS III.
Article in Movement disorders clinical practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
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Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Robot-Assisted versus non-robotic frame-based deep brain stimulation: a systematic review and meta-analysis of targeting accuracy and clinical outcomes.Journal of robotic surgery · 2026Pooled it
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMDS-UPDRS Severity Levels (SLs), derived from clinician- and patient-rated scales, remain underused to evaluate response to subthalamic deep brain stimulation (STN-DBS) in patients with Parkinson's disease (PD).
objectivesTo evaluate MDS-UPDRS SL as markers of STN-DBS response.
methodsSLs were categorized as mild, moderate, or severe using established cut-off points for Parts II, III Off, and IV. Improvement was defined as a decrease in at least one SL. Part III Off improvement was correlated to quality-of-life scales and used to predict SL improvement using ROC Curve analysis.
resultsA total of 51 patients (34.1% female, aged 58.9 ± 10.2 years, disease duration 12.3 ± 4.1 years) were evaluated 12 months after surgery. MDS-UPDRS III Off changes over 30% predicted SL improvements in MDS-UPDRS II (AUC = 0.83, p = 0.015) and IV (AUC = 0.89, p = 0.001).
conclusionOur findings suggest that improvement in MDS-UPDRS SL are potential markers of STN-DBS response. With an MDS-UPDRS part III improvement around 30% predicting SL improvement.
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