Evidence map›Paper›PMID 40879132›Full record

ArticleeLife2025

Identifying in vivo genetic dependencies of melanocyte and melanoma development.

Sarah Perlee, Yilun Ma, Miranda V Hunter, Jacob B Swanson, Nelly M Cruz, Zhitao Ming, Julia Xia, Timothee Lionnet, Maura McGrail, Richard M White

Abstract read
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Sarah PerleeDepartment of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, United States.ORCID https://orcid.org/0000-0003-3295-6755
Yilun MaDepartment of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, United States.ORCID https://orcid.org/0000-0002-2297-9980
Miranda V HunterDepartment of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, United States.ORCID https://orcid.org/0000-0002-6971-1738
Jacob B SwansonInstitute for Systems Genetics, NYU Grossman School of Medicine, New York, United States.
Nelly M CruzDepartment of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, United States.ORCID https://orcid.org/0000-0002-9040-6957
Zhitao MingDepartment of Genetics, Development and Cell Biology, Iowa State University, Ames, United States.
Julia XiaDepartment of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, United States.
Timothee LionnetInstitute for Systems Genetics, NYU Grossman School of Medicine, New York, United States.ORCID https://orcid.org/0000-0003-1508-0202
Maura McGrailDepartment of Genetics, Development and Cell Biology, Iowa State University, Ames, United States.ORCID https://orcid.org/0000-0001-9308-6189
Richard M WhiteDepartment of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, United States.ORCID https://orcid.org/0000-0001-9099-9169

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
Weill Cornell/Rockefeller/Sloan-Kettering MST ProgramT32GM007739 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI HSU, KATHARINE C · 1985 to 2023
$51.1M
In vivo model of microglia inflammasome signaling in neuroinflammationR24OD020166 · OD · IOWA STATE UNIVERSITY · PI CLARK, KARL J, EKKER, STEPHEN CARL · 2016 to 2023
$7.1M
Weill Cornell/Rockefeller/Sloan Kettering MST ProgramT32GM152349 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI KATHARINE C HSU · 2024 to 2026
$6.6M
Dissecting the complexity of metastasis with mathematical models and quantitative experiments with in zebrafishR01CA229215 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI WHITE, RICHARD MARK, XAVIER, JOAO · 2018 to 2022
$3.1M
Conditional genetics and precision genome editing resources for ZebrafishR24OD036201 · OD · IOWA STATE UNIVERSITY · PI KARL J CLARK, Stephen Carl Ekker · 2024 to 2026
$3.0M
Evolutionary dynamics of melanoma metastasisDP2CA186572 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI WHITE, RICHARD MARK · 2013 to 2013
$2.7M
Molecular Imaging in Cancer Biology Training ProgramT32CA254875 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI Jason S. Lewis, Michael H. Overholtzer · 2021 to 2026
$2.1M
Lipid programs in melanocyte transformationR01CA238317 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI OVERHOLTZER, MICHAEL H., WHITE, RICHARD MARK · 2020 to 2025
$2.0M
The role of the novel interface cell state in melanoma invasionK99CA266931 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI HUNTER, MIRANDA VICTORIA · 2023 to 2024
$346k
In vivo characterization of keratinocytes in the melanoma microenvironmentF30CA265124 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI MA, YILUN · 2021 to 2024
$206k
Investigating the role of melanoma-adipocyte cell junctions in heterotypic communication and tumor progressionF31CA271518 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI PERLEE, SARAH · 2023 to 2024
$73k
Ludwig Institute for Cancer Research Core GrantNCI NIH HHS 1K99CA266931NCI NIH HHS DP2 CA186572NCI NIH HHS F30 CA265124NCI NIH HHS F30CA265124NCI NIH HHS F31 CA271518NCI NIH HHS F31CA271518NCI NIH HHS K99 CA266931NCI NIH HHS P30 CA008748NCI NIH HHS R01 CA229215NCI NIH HHS R01 CA238317NCI NIH HHS T32 CA254875NCI NIH HHS T32CA254875NIGMS NIH HHS T32 GM007739NIGMS NIH HHS T32 GM152349NIH HHS DP2CA186572NIH HHS ORIP R24OD020166NIH HHS R01CA229215NIH HHS R01CA238317NIH HHS R24 OD020166NIH HHS R24 OD036201NIH HHS T32GM007739
6 · The paper itself

Abstract

The advent of large-scale sequencing in both development and disease has identified large numbers of candidate genes that may be linked to important phenotypes. We have developed a rapid, scalable system for assessing the role of candidate genes using zebrafish. We generated transgenic zebrafish in which Cas9 was knocked in to the endogenous

Indexed as

MelanocytesMelanomaAnimalsAnimals, Genetically ModifiedCRISPR-Cas SystemsMicrophthalmia-Associated Transcription FactorZebrafishZebrafish ProteinsMicrophthalmia-Associated Transcription Factormitfa protein, zebrafishZebrafish ProteinsCRISPR-Cas9geneticsgenomicsmelanocytesmelanomazebrafish

Identifiers

PMID40879132
PMCPMC12396812

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.