ArticleEnvironmental and molecular mutagenesis2025
Molecular Impacts of Occupational Exposure to Waste Anesthetic Gases.
Article in Environmental and molecular mutagenesis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Genetic biomarkers and individual susceptibility in healthcare workers exposed to waste anesthetic gases: a systematic review and meta-analysis.Frontiers in medicine · 2026Pooled it
- Molecular Impacts of Occupational Exposure to Waste Anesthetic Gases.Environmental and molecular mutagenesis · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Millions of healthcare professionals are occupationally exposed to waste anesthetic gases (WAGs) worldwide; however, their effect on DNA methylation is unknown. Thus, for the first time, global DNA methylation analysis was performed in addition to the comet assay and gene expression analysis in this case-control study to reveal possible molecular alterations associated with WAG exposure. A total of 86 participants were included (43 healthcare professionals exposed to WAGs and 43 matched-controls). Mononuclear cells were isolated for the comet assay, and DNA was extracted from whole blood for global DNA methylation analysis. RNA was isolated for the gene expression of NRF2, SIRT1, and HO1. Increased DNA damage was observed in the exposed group (p = 0.02). No differences in global DNA methylation or HO1 expression were observed (p > 0.05), but SIRT1 (p = 0.01) and NRF2 (p = 0.02) upregulation were observed in the exposed group. These findings highlight the molecular effects of WAG exposure.
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