Evidence map›Paper›PMID 40879084›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2025

A Mouse Model of Partial Pancreas Agenesis Induced by Polo-like kinase 1 Mutation.

Xiyue Chen, Zhihao Jia, Shihuan Kuang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. A Mouse Model of Partial Pancreas Agenesis Induced by Polo-like kinase 1 Mutation.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Xiyue ChenDepartment of Animal Sciences, Purdue University, West Lafayette, Indiana, USA.ORCID https://orcid.org/0009-0007-0598-6189
Zhihao JiaDepartment of Animal Sciences, Purdue University, West Lafayette, Indiana, USA.ORCID https://orcid.org/0000-0001-5525-2721
Shihuan KuangDepartment of Animal Sciences, Purdue University, West Lafayette, Indiana, USA.ORCID https://orcid.org/0000-0001-9180-3180

Funding

Immunomyoblasts in muscle regenerationR01AR078695 · NIAMS · PURDUE UNIVERSITY · PI KUANG, SHIHUAN · 2021 to 2025
$2.2M
Metabolic regulation of muscle satellite cell homeostasisR01DK132819 · NIDDK · PURDUE UNIVERSITY · PI Shihuan Kuang · 2023 to 2026
$2.0M
Targeting PTEN to ameliorate muscular dystrophy in a mouse modelR01AR079235 · NIAMS · PURDUE UNIVERSITY · PI KUANG, SHIHUAN · 2022 to 2025
$1.3M
HHS | NIH | National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) R01AR078695HHS | NIH | National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) R01AR079235HHS | NIH | National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) R01DK132819NIAMS NIH HHS R01 AR078695NIAMS NIH HHS R01 AR079235NIDDK NIH HHS R01 DK132819
6 · The paper itself

Abstract

The pancreas regulates metabolic homeostasis through exocrine and endocrine pathways. Dysfunction or loss of pancreatic β-cells causes diabetes. Here we explore the role of Polo-like kinase 1 (PLK1) in the pancreas using a pancreatic-lineage specific knockout (Plk1

Indexed as

Cell Cycle ProteinsMutationPancreasProtein Serine-Threonine KinasesProto-Oncogene ProteinsAnimalsDisease Models, AnimalMaleMiceMice, Inbred C57BLMice, KnockoutPolo-Like Kinase 1Cell Cycle ProteinsPolo-Like Kinase 1Protein Serine-Threonine KinasesProto-Oncogene Proteinsdiabetes mellitushyperglycemiainsulinmetabolismpancreaspolo‐like kinase 1

Identifiers

PMID40879084
PMCPMC12345124

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.