Evidence map›Paper›PMID 40879082›Full record

ArticleCancer medicine2025

Does First-Time Colon Cancer Screening Beyond Age 75 Reduce Cancer Risk Without Significant Complications? Insights From a Large US Retrospective Study.

Azhar Hussain, Ruchir Paladiya, Muhammad Shahzil, Shiza Sarfraz, Kalsoom Khalil, Umar Hayat, Dushyant Singh Dahiya, Hassam Ali

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Azhar HussainDepartment of Internal Medicine, SUNY Upstate Medical University, Syracuse, New York, USA.
Ruchir PaladiyaDepartment of Internal Medicine, University of Connecticut Health Center, Farmington, Connecticut, USA.
Muhammad ShahzilDepartment of Internal Medicine, Penn State Health Milton S Hershey Medical Center, The Pennsylvania State University, Hershey, Pennsylvania, USA.ORCID https://orcid.org/0000-0002-4010-7545
Shiza SarfrazDepartment of Internal Medicine, ECU Health Medical Center, Greenville, North Carolina, USA.
Kalsoom KhalilDepartment of Internal Medicine, Lahore General Hospital, Lahore, Pakistan.
Umar HayatDepartment of Internal Medicine, Geisinger Wyoming Valley Medical Center, Wilkes-Barre, Pennsylvania, USA.
Dushyant Singh DahiyaDivision of Gastroenterology, Hepatology & Motility, The University of Kansas School of Medicine, Kansas City, Kansas, USA.
Hassam AliDepartment of Gastroenterology, Hepatology & Nutrition, ECU Health Medical Center/Brody School of Medicine, Greenville, North Carolina, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionColorectal cancer (CRC) is a leading cause of global cancer-related morbidity and mortality. This study examines the impact of first-time screening colonoscopy on CRC incidence in obese individuals aged 75 and older using a large US retrospective cohort.

methodsObese adults aged ≥ 75 were divided into two groups: those undergoing their first screening colonoscopy after 75 (Cases) and those without prior colonoscopy (Controls), using TrinetX database data.

resultsPropensity-matched cohorts of 123,930 patients each showed reduced CRC incidence (0.08% vs. 0.52%; OR: 0.157, p < 0.001) and lower all-cause mortality (9.6% vs. 17.3%; OR: 0.510, p < 0.001) in the colonoscopy group. The number needed to treat to prevent one CRC case was 227. Perforation rates were similar (0.2%, p = NS), but gastrointestinal bleeding was higher (5.2% vs. 4.4%; OR: 1.187, p < 0.001).

conclusionScreening colonoscopy after age 75 significantly reduces CRC incidence and mortality, with manageable complication rates.

Indexed as

Colonic NeoplasmsColonoscopyColorectal NeoplasmsEarly Detection of CancerAgedAged, 80 and overAge FactorsFemaleHumansIncidenceMaleMass ScreeningObesityRetrospective StudiesRisk FactorsUnited Statesaged 75 and overcolonoscopycolorectal neoplasmsobesityretrospective studies

Identifiers

PMID40879082
PMCPMC12395350

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.