Evidence map›Paper›PMID 40879081›Full record

ArticleAdvanced healthcare materials2025

Nitric Oxide-Releasing Catheters with Phenol-Amine Catalytic Coatings for Improved Anti-Inflammatory Performance.

Qingqing Fan, Shu Geng, Tanveer A Tabish, Kang Lin, Yiyi Yin, Siti Nur Asyura Adzlan, Federico Mazur, Rona Chandrawati

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced healthcare materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Qingqing FanSchool of Chemical Engineering and Australian Centre for Nanomedicine (ACN), The University of New South Wales, Sydney, NSW, 2052, Australia.
Shu GengSchool of Chemical Engineering and Australian Centre for Nanomedicine (ACN), The University of New South Wales, Sydney, NSW, 2052, Australia.
Tanveer A TabishDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, British Heart Foundation (BHF) Centre of Research Excellence, University of Oxford, Headington, Oxford, OX3 7BN, UK.
Kang LinSchool of Chemical Engineering and Australian Centre for Nanomedicine (ACN), The University of New South Wales, Sydney, NSW, 2052, Australia.
Yiyi YinSchool of Chemical Engineering and Australian Centre for Nanomedicine (ACN), The University of New South Wales, Sydney, NSW, 2052, Australia.
Siti Nur Asyura AdzlanSchool of Chemical Engineering and Australian Centre for Nanomedicine (ACN), The University of New South Wales, Sydney, NSW, 2052, Australia.
Federico MazurSchool of Chemical Engineering and Australian Centre for Nanomedicine (ACN), The University of New South Wales, Sydney, NSW, 2052, Australia.
Rona ChandrawatiSchool of Chemical Engineering and Australian Centre for Nanomedicine (ACN), The University of New South Wales, Sydney, NSW, 2052, Australia.ORCID 0000-0002-9780-8844

Funding

British Heart Foundation FS/ATA/21/20015National Health and Medical Research Council APP1173428Royal Society IES∖R1∖231168
6 · The paper itself

Abstract

Nitric oxide (NO) is a signaling molecule critical for vasodilation, bacterial inhibition, and inflammation modulation, making it valuable for medical devices, such as catheters. However, existing NO-releasing catheters face challenges, including maintaining stable NO release over time and complex manufacturing processes. In this study, a robust nanocoating made from tannic acid (TA) and selenocystamine (SeCA) is presented, designed to catalytically generate NO from S-nitrosoglutathione in the presence of glutathione. Surface characterization techniques confirmed successful coating formation, with optimal NO generation achieved at a 1:4 TA:SeCA molar ratio. The coated catheters maintained over 96% viability of human coronary artery smooth muscle cells (HCASMCs) after 72 h. It has been demonstrated that the modified catheters significantly increased endogenous NO production in HCASMCs from intracellular S-nitrosothiols, highlighting their potential to support vascular function. The coating sustained NO release at 7 × 10

Indexed as

AminesAnti-Inflammatory AgentsCathetersCoated Materials, BiocompatibleNitric OxidePhenolAnimalsCatalysisCell SurvivalCystamineHumansMiceMyocytes, Smooth MuscleRAW 264.7 CellsS-NitrosoglutathioneTanninsAminesAnti-Inflammatory AgentsCoated Materials, BiocompatibleCystamineNitric OxidePhenolS-NitrosoglutathioneTanninscathetersnitric oxideselenocystamineS‐nitrosoglutathionetannic acid

Identifiers

PMID40879081
PMCPMC12683202

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.