Evidence map›Paper›PMID 40879041›Full record

ArticleAnimal models and experimental medicine2025

Establishment of a patient-derived drug-resistant oral squamous cell carcinoma animal model.

Chuanni Feng, Hao Liu, Yalan Lu, Yanfeng Xu, Xinghan Wu, Jinlong Wang, Chuan Qin, Binbin Li, Yanhong Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Animal models and experimental medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Chuanni FengNHC Key Laboratory of Human Disease Comparative Medicine, Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases, International Center for Technology and Innovation of Animal Model, Comparative Medicine Center, Institute of Laboratory Animal Sciences, Peking Union Medical College (PUMC), Chinese Academy of Medical Sciences (CAMS), Beijing, China.ORCID 0009-0007-2684-1448
Hao LiuThe Central Laboratory, Peking University School and Hospital of Stomatology, Beijing, China.ORCID 0000-0003-0977-5884
Yalan LuNHC Key Laboratory of Human Disease Comparative Medicine, Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases, International Center for Technology and Innovation of Animal Model, Comparative Medicine Center, Institute of Laboratory Animal Sciences, Peking Union Medical College (PUMC), Chinese Academy of Medical Sciences (CAMS), Beijing, China.
Yanfeng XuNHC Key Laboratory of Human Disease Comparative Medicine, Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases, International Center for Technology and Innovation of Animal Model, Comparative Medicine Center, Institute of Laboratory Animal Sciences, Peking Union Medical College (PUMC), Chinese Academy of Medical Sciences (CAMS), Beijing, China.
Xinghan WuNHC Key Laboratory of Human Disease Comparative Medicine, Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases, International Center for Technology and Innovation of Animal Model, Comparative Medicine Center, Institute of Laboratory Animal Sciences, Peking Union Medical College (PUMC), Chinese Academy of Medical Sciences (CAMS), Beijing, China.
Jinlong WangNHC Key Laboratory of Human Disease Comparative Medicine, Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases, International Center for Technology and Innovation of Animal Model, Comparative Medicine Center, Institute of Laboratory Animal Sciences, Peking Union Medical College (PUMC), Chinese Academy of Medical Sciences (CAMS), Beijing, China.ORCID 0009-0003-3284-3643
Chuan QinNHC Key Laboratory of Human Disease Comparative Medicine, Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases, International Center for Technology and Innovation of Animal Model, Comparative Medicine Center, Institute of Laboratory Animal Sciences, Peking Union Medical College (PUMC), Chinese Academy of Medical Sciences (CAMS), Beijing, China.ORCID 0000-0002-6261-1232
Binbin LiDepartment of Oral Pathology, Peking University School and Hospital of Stomatology, Beijing, China.
Yanhong LiNHC Key Laboratory of Human Disease Comparative Medicine, Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases, International Center for Technology and Innovation of Animal Model, Comparative Medicine Center, Institute of Laboratory Animal Sciences, Peking Union Medical College (PUMC), Chinese Academy of Medical Sciences (CAMS), Beijing, China.

Funding

Beijing Natural Science Foundation 7252096Beijing Natural Science Foundation-Haidian Original Innovation Joint Fund Project L222145National Natural Science Foundation of China 82173399Young Elite Scientists Sponsorship Program by CAST 2022QNRC001
6 · The paper itself

Abstract

Oral squamous cell carcinoma (OSCC) constitutes 90% of oral tumors. Advanced cases severely impair patients' life quality of life due to anatomical location and limited therapies. Conventional treatments often induce drug resistance or recurrence. Patient-derived xenograft (PDX) models are widely used to simulate tumor progression and drug responses, serving as translational tools for precision medicine. This study aimed to establish drug-resistant OSCC PDX models. Human OSCC tissues were transplanted into immunodeficient mice and passaged (P1-P2). At P2 (tumor volume: 40-80 mm

Indexed as

Carcinoma, Squamous CellDisease Models, AnimalDrug Resistance, NeoplasmMouth NeoplasmsAnimalsAntineoplastic AgentsCetuximabCisplatinFemaleHumansMaleMiceMice, SCIDSirolimusXenograft Model Antitumor AssaysAntineoplastic AgentsCetuximabCisplatinSirolimusdrug resistanceoral squamous cell carcinomaPDX modelprecision therapysuccessive passaging

Identifiers

PMID40879041
PMCPMC12464870

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.