ArticleJournal of the American Heart Association2025
Commissural Fiber Disruption Is Associated With Symptom Onset in Cerebral Autosomal-Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy.
Article in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundExtensive white matter hyperintensities are a hallmark of cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), a monogenic small-vessel disease caused by pathogenic
methodsA total of 161 participants were recruited, including 60 patients with symptomatic CADASIL, 67 preclinical
resultsAmong fiber tracts, commissural fiber PSMD exhibited the strongest correlations with cognitive function and disability, explaining the most variance (40%-60%). Symptomatic patients with CADASIL had significantly higher commissural fiber PSMD values (5.78±1.94×10
conclusionsCommissural fiber PSMD may serve as a robust biomarker for assessing disease severity and progression in CADASIL. These findings highlight its potential clinical utility in patient stratification and prognostication.
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