ArticleSmall (Weinheim an der Bergstrasse, Germany)2025
Predicting the Dominant Role of Dense Aggregates in Magnetic Hyperthermia via Intracellular-Mimetic Nanoparticle Models.
Article in Small (Weinheim an der Bergstrasse, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Magneto-X Effects in Magnetic Soft Materials and Their Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Predicting the Dominant Role of Dense Aggregates in Magnetic Hyperthermia via Intracellular-Mimetic Nanoparticle Models.Small (Weinheim an der Bergstrasse, Germany) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Dense aggregation of magnetic nanoparticles (MNPs) in cellular environments is a major contributor to reduced magnetic hyperthermia (MH) efficiency; however, in situ magnetic characterization remains challenging, necessitating reliable extracellular models to predict such behavior. In this study, soft and dense aggregates (≈200 nm) are engineered using 10 nm iron oxide MNPs, encapsulated in polymeric (soft) or inorganic (dense) shells, with morphological features and strong magnetic dipolar interactions confirming their similarity to nanoparticle assemblies found in living cells. Unlike previous studies that induced aggregation by modifying the surrounding medium, the approach enables controlled, invariant aggregation states, allowing systematic evaluation of the transition from soft to dense aggregation under both aqueous and high-viscosity, cell-mimicking conditions. Results demonstrate that dense aggregation leads to a >20% reduction in specific absorption rate (SAR), primarily due to decreased remanent magnetization (M
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Registered trials
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