Evidence map›Paper›PMID 40878993›Full record

ArticleJournal of the American Heart Association2025

Effect of Cardiac Arrest Center Protocol Implementation on Survival After Nontraumatic Out-of-Hospital Cardiac Arrest.

Georg Stachel, Lisa Ruft, Niklas Hertenberger, Gerrit Eichner, Karsten Lenk, Dominik Michalski, Joseph Classen, Sirak Petros, Sebastian Stehr, Ulrich Laufs and 1 more

Abstract read
In one paragraph

Article in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Letter to the Editor: 250th cardiac arrest center certification in Germany.Clinical research in cardiology : official journal of the German Cardiac Society · 2025
    Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Georg StachelEmergency Department and Observation Ward University Hospital Leipzig Germany.ORCID 0000-0001-9901-5429
Lisa RuftEmergency Department and Observation Ward University Hospital Leipzig Germany.
Niklas HertenbergerEmergency Department and Observation Ward University Hospital Leipzig Germany.
Gerrit EichnerMathematical Institute Justus-Liebig-University Giessen Germany.ORCID 0000-0001-9523-5520
Karsten LenkDepartment of Cardiology University Hospital Leipzig Germany.ORCID 0000-0001-5868-4159
Dominik MichalskiCardiac Arrest Center University Hospital Leipzig Germany.ORCID 0000-0002-0206-5380
Joseph ClassenCardiac Arrest Center University Hospital Leipzig Germany.ORCID 0000-0001-7182-6967
Sirak PetrosCardiac Arrest Center University Hospital Leipzig Germany.ORCID 0000-0002-2345-756X
Sebastian StehrCardiac Arrest Center University Hospital Leipzig Germany.ORCID 0000-0003-0635-5112
Ulrich LaufsDepartment of Cardiology University Hospital Leipzig Germany.ORCID 0000-0003-2620-9323
André GriesEmergency Department and Observation Ward University Hospital Leipzig Germany.ORCID 0000-0003-4801-6987

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEvidence on the effect of treatment at a cardiac arrest center (CAC) on clinical outcomes is incomplete and conflicting. The aim was to evaluate the effect of treatment at a CAC on survival after out-of-hospital cardiac arrest.

methodsFor this retrospective cohort study, data from all 790 consecutive patients admitted to our center from January 2018 to May 2023 after nontraumatic out-of hospital cardiac arrest were analyzed. All CAC protocols were completely introduced in October 2020. The primary end point was death or unfavorable neurological outcome (cerebral performance category 3-5) at 90 days. Patients were stratified by Cardiac Arrest Survival Score.

resultsWe compared 432 patients (54.7%) managed before to 358 patients (45.3%) after full CAC implementation. Their median age was 68 (interquartile range, 56-78) years before and 67 (interquartile range, 55-78) thereafter. Cardiac Arrest Survival Score was significantly higher before CAC introduction (median, 28.9% [interquartile range, 8.78-59.9]) than after (6.9% [interquartile range, 1.1-23.3];

conclusionsCoordinated and specialized treatment in a certified CAC may not impact outcomes in patients with low survival probability after nontraumatic out-of-hospital cardiac arrest, but appears to improve survival in patients with intermediate and high survival probability.

Indexed as

Cardiopulmonary ResuscitationClinical ProtocolsOut-of-Hospital Cardiac ArrestAgedFemaleHumansMaleMiddle AgedRetrospective StudiesSurvival RateTime FactorsTreatment Outcomecardiac arrest centerCardiac Arrest Survival Score (CRASS)out‐of‐hospital cardiac arrestresuscitationtreatment algorithmstreatment quality

Identifiers

PMID40878993
PMCPMC12553427

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.