ArticleJournal of the American Heart Association2025
Characterizing Stroke Clots Using Single-Cell Sequencing.
Article in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- The Defect of iNKT Cells Mediates Mitochondrial Dysfunction Through IL-6/STAT3 Signaling to Induce Atrial Inflammation and Fibrosis to Aggravate Postoperative Atrial Fibrillation.Physiological research · 2026Article
- Analytical Methods and Application of Single-Cell and Single-Nucleus Transcriptomics in the Study of Ischemic Stroke.Biomolecules · 2026Review
- Clot Composition and Ischemic Stroke Etiology: A Contemporary Narrative Review.Journal of clinical medicine · 2025Review
- CLIC1 down-regulates Nrf2/HO-1 signalling pathway promoting the apoptosis and pyroptosis in OGD/R-treated HT22 cells.PloS one · 2025Article
- Article
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Authors and funding
18 authors.
Funding
Abstract
backgroundIschemic stroke results in significant morbidity and mortality. By examining gene expression of cells comprising stroke clots, we aim to gain valuable insights into the underlying mechanisms of this disease and identify potential biomarkers of stroke cause.
methodsWe employed single-cell RNA sequencing to analyze 10 clot samples from patients diagnosed with large vessel occlusion stroke. We aimed to identify and compare the immune cell compositions and gene expression profiles between stroke clots (atrial fibrillation vs carotid atherosclerosis). We also used Multi-marker Analysis of Genomic Annotation and genome-wide association studies summary statistics from the GIGASTROKE consortium to assess associations between genetic variants and cell type-specific gene expression within the stroke subtypes.
resultsOur analysis revealed distinct immune cell populations, including monocytes, macrophages, dendritic cells, neutrophils, and T cells in both clot types. Notably, we observed significant differences in gene expression within the mononuclear phagocytic system cells between clots from patients with atrial fibrillation and carotid atherosclerosis. We identified specific genes associated with atherosclerosis and stroke-related processes, such as
conclusionsThis study illuminates the immune and transcriptomic landscape within clots, offering potential biomarkers and lays the foundation for future research.
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