ReviewMolecular medicine reports2025
Circular RNAs: Fundamental mechanisms in tumor metastasis and detection strategies (Review).
Review in Molecular medicine reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
7 authors.
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Abstract
As a class of endogenous non‑coding RNAs, circular RNAs (circRNAs) are produced by an event known as back‑splicing. Although circRNAs were initially considered to be the product of abnormal splicing events, increasing evidence has shown their vital role in the development of various diseases, especially malignant tumors. Tumor metastasis is the leading cause of tumor deterioration and cancer‑associated mortality, and involves biological changes to malignant cells. A number of circRNAs can mediate tumor progression, especially tumor metastasis. Furthermore, due to their unique structural features, circRNAs are highly stable in body fluids, and have temporal and tissue specificity, making them potentially ideal non‑invasive biomarkers for sensitive monitoring of tumor changes. The present review focuses on circRNAs associated with tumor metastasis and discusses their functional mechanisms. Furthermore, the current review summarizes advances regarding circRNAs as biomarkers and detection strategies.
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