Evidence map›Paper›PMID 40878925›Full record

ArticleGenes, chromosomes & cancer2025

Pseudoglandular Schwannoma With FUS::KLF17 Fusion: Broadening the Spectrum of FUS-Associated Tumors.

Jerome Givi, Daisy Wu, Rania Bakkar, Michelle Afkhami, Diana Bell

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Article in Genes, chromosomes & cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jerome GiviDepartment of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.ORCID 0000-0002-8180-5446
Daisy WuDepartment of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
Rania BakkarDepartment of Pathology, City of Hope Cancer Center, Duarte, California, USA.
Michelle AfkhamiDepartment of Pathology, City of Hope Cancer Center, Duarte, California, USA.ORCID 0000-0001-5830-6158
Diana BellDepartment of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.ORCID 0000-0002-3531-8241

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We present a case of a 51-year-old male with a pseudoglandular cellular schwannoma arising from the brachial plexus, which contains the expected molecular aberrations for a schwannoma (chromosome 22q loss encompassing the NF2 and LZTR1 genes) as well as a FUS::KLF17 rearrangement. Pseudoglandular schwannomas are rare morphologic variants of schwannomas that contain gland-like spaces lined by S100-positive, cytokeratin-negative pseudocolumnar Schwann cells. Fusions involving FUS and EWSR are commonly found in myoepithelial tumors of bone and soft tissue. While the spectrum of tumors with fusions involving FUS and EWSR is relatively broad, no cases, to our knowledge, have been reported of schwannomas, let alone the morphologically distinct pseudoglandular schwannoma, containing a FUS rearrangement. This case thus expands the spectrum of FUS rearranged tumors, highlighting the need for documentation of similar cases to understand the clinical significance of this combination.

Indexed as

NeurilemmomaOncogene Proteins, FusionRNA-Binding Protein FUSTranscription FactorsBrachial PlexusHumansMaleMiddle AgedFUS protein, humanOncogene Proteins, FusionRNA-Binding Protein FUSTranscription FactorsFUSKLF17myoepithelial tumorpseudoglandular schwannomaschwannoma

Identifiers

PMID40878925
PMCPMC12340572

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