Evidence map›Paper›PMID 40878909›Full record

ArticleeLife2025

The long noncoding RNA lnc-FANCI-2 intrinsically restricts RAS signaling in human papillomavirus type 16-infected cervical cancer cells.

Haibin Liu, Lulu Yu, Vladimir Majerciak, Thomas J Meyer, Ming Yi, Peter F Johnson, Maggie Cam, Douglas R Lowy, Zhi-Ming Zheng

Abstract read
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Haibin Liu *Tumor Virus RNA Biology Section, HIV Dynamics and Replication Program, CCR/NCI/NIH, Frederick, United States.ORCID https://orcid.org/0000-0003-3601-6066
Lulu Yu *Tumor Virus RNA Biology Section, HIV Dynamics and Replication Program, CCR/NCI/NIH, Frederick, United States.ORCID https://orcid.org/0000-0003-0309-9520
Vladimir MajerciakTumor Virus RNA Biology Section, HIV Dynamics and Replication Program, CCR/NCI/NIH, Frederick, United States.
Thomas J MeyerCollaborative Bioinformatics Resource, CCR/NCI/NIH, Bethesda, United States.
Ming YiNCI RAS Initiative, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Frederick, United States.
Peter F JohnsonMouse Cancer Genetics Program, CCR/NCI/NIH, Frederick, United States.
Maggie CamCollaborative Bioinformatics Resource, CCR/NCI/NIH, Bethesda, United States.
Douglas R LowyLaboratory of Cellular Oncology, CCR/NCI/NIH, Bethesda, United States.
Zhi-Ming ZhengTumor Virus RNA Biology Section, HIV Dynamics and Replication Program, CCR/NCI/NIH, Frederick, United States.ORCID https://orcid.org/0000-0001-5547-7912

Funding

Gene Expression and Post-Transcriptional Regulation of DNA Tumor VirusesZIASC010357 · NCI · DIVISION OF CLINICAL SCIENCES - NCI · PI ZHENG, ZHI-MING · 2009 to 2025
$24.3M
Intramural NIH HHS ZIA SC010357The Intramural Research Program of the NIH, NCI, Center for Cancer Research ZIA SC 010357
6 · The paper itself

Abstract

Increased expression of lnc-FANCI-2, a newly discovered long noncoding RNA, is associated with cervical lesion progression from cervical intraepithelial neoplasia stage 1 (CIN1, low grade), CIN2-3 (high grade), to cervical cancer. Viral oncoprotein E7 of high-risk human papillomaviruses (HR-HPVs) and host transcription factor YY1 are two major factors promoting lnc-FANCI-2 expression. Using CRISPR-Cas9 technology, we knocked out the expression of

Indexed as

Human papillomavirus 16Papillomavirus Infectionsras ProteinsRNA, Long NoncodingSignal TransductionUterine Cervical NeoplasmsCell Line, TumorFemaleGene Knockout TechniquesHumansras ProteinsRNA, Long Noncodingcancer biologycervical cancerHPVhumaninfectious diseaselnc-FANCI-2microbiologynoncoding RNARAS signalingRNA biology

Identifiers

PMID40878909
PMCPMC12396819

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.