Evidence map›Paper›PMID 40878818›Full record

ArticleMolecular oncology2025

Multi-omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine.

Livia Concetti, Manuel Scimeca, Julia Bischof, Jonathan Woodsmith, Massimiliano Agostini, Cristina Fiorani, Yufang Shi, Eleonora Candi, Gerry Melino, Alessandro Mauriello and 1 more

Abstract readCase Reports
In one paragraph

Article in Molecular oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Livia ConcettiDepartment of Experimental Medicine, TOR, University of Rome "Tor Vergata", Italy.
Manuel ScimecaDepartment of Experimental Medicine, TOR, University of Rome "Tor Vergata", Italy.ORCID 0000-0003-0585-1309
Julia BischofIndivumed GmbH, Falkenried, Hamburg, Germany.
Jonathan WoodsmithIndivumed GmbH, Falkenried, Hamburg, Germany.
Massimiliano AgostiniDepartment of Experimental Medicine, TOR, University of Rome "Tor Vergata", Italy.
Cristina FioraniDepartment of Surgical Science, University of Rome "Tor Vergata", Italy.
Yufang ShiThe Fourth Affiliated Hospital of Soochow University, Institutes for Translational Medicine, Suzhou Medical College, Soochow University, Suzhou, China.
Eleonora CandiDepartment of Experimental Medicine, TOR, University of Rome "Tor Vergata", Italy.
Gerry MelinoDepartment of Experimental Medicine, TOR, University of Rome "Tor Vergata", Italy.
Alessandro MaurielloDepartment of Experimental Medicine, TOR, University of Rome "Tor Vergata", Italy.ORCID 0000-0002-7351-5676
Giuseppe S SicaDepartment of Surgical Science, University of Rome "Tor Vergata", Italy.ORCID 0000-0002-7407-0584

Funding

Associazione Italiana per la Ricerca sul Cancro IG 2022Associazione Italiana per la Ricerca sul Cancro IG 22206Lazio Innova 55-2021-T0002E0001Lazio Innova 85-2017-14986Ministry of Health & MAECI Italy-China Science and Technology Cooperation PGR00961MUR-PNRR M4C2I1.3 PE6 project PE00000019 Heal Italia CUP: E83C22004670001
6 · The paper itself

Abstract

Colorectal cancer (CRC) is a heterogenous disease with distinct biological and clinical subgroups, each with different prognoses and responses to therapy. In this case report, taking inspiration from a case of locally advanced CRC with serine/threonine-protein kinase B-raf (BRAF) V600E mutation, we highlight an atypical consensus molecular subtype 1 (CMS1). Deep multi-omic analyses showed a limited expression of programmed cell death protein 1 (PD-1) and reduced T-cell infiltration, including CD8

Indexed as

Colorectal NeoplasmsImmunityPrecision MedicineHumansMultiomicsMutationCMS1, immune responsecolorectal cancerJAK/STATpersonalized medicine

Identifiers

PMID40878818
PMCPMC12688173

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.