Evidence map›Paper›PMID 40878776›Full record

ArticleJournal of biomedical research2026

hUMSC-derived exosomes alleviate hypoxic cerebrovascular injury

Jinteng Liu, Yunlong Pan, Haolin Wu, Qingyun Guo, Xingyue Fang, Yingmei Lu, Qibing Liu

Abstract read
In one paragraph

Article in Journal of biomedical research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jinteng LiuDepartment of Pharmacy & Engineering Research Center of Tropical Medicine Innovation and Transformation, the First Affiliated Hospital & School of Pharmacy of Hainan Medical University, Haikou, Hainan 570102, China.
Yunlong PanKey Laboratory of Modern Toxicology of Ministry of Education; School of Basic Medical Sciences, Nanjing Medical University, Nanjing, Jiangsu 211166, China.
Haolin WuInternational Research Center on Aging and Tumor, Hainan Medical University, Haikou, Hainan 571199, China.
Qingyun GuoKey Laboratory of Brain Science Research & Transformation in Tropical Environment of Hainan Province, Hainan Medical University, Haikou, Hainan 571199, China.
Xingyue FangDepartment of Pharmacy & Engineering Research Center of Tropical Medicine Innovation and Transformation, the First Affiliated Hospital & School of Pharmacy of Hainan Medical University, Haikou, Hainan 570102, China.
Yingmei LuKey Laboratory of Modern Toxicology of Ministry of Education; School of Basic Medical Sciences, Nanjing Medical University, Nanjing, Jiangsu 211166, China.
Qibing LiuDepartment of Pharmacy & Engineering Research Center of Tropical Medicine Innovation and Transformation, the First Affiliated Hospital & School of Pharmacy of Hainan Medical University, Haikou, Hainan 570102, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As the most prevalent cause of death worldwide, ischemic stroke urgently requires innovative therapeutic strategies. The present study demonstrated the therapeutic potential of human umbilical cord-derived mesenchymal stem cell-derived exosomes (hUMSC-Exos) in ameliorating hypoxia-induced cerebrovascular endothelial dysfunction through modulation of the AMPK/NLRP3 signaling pathway. Bioinformatics analysis of DisGeNET and exosomal cargo databases revealed 283 overlapping cerebral ischemia-related genes, implicating hUMSC-Exos in inflammatory regulation.

Indexed as

AMPK/NLRP3 signaling pathwayhUMSC-Exospyroptosisstrokesynergistic combination therapy

Identifiers

PMID40878776
PMCPMC13231368

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.