Evidence map›Paper›PMID 40878760›Full record

ArticleAmerican journal of epidemiology2026

The "long arm of childhood" on mortality in older adulthood in the United States and Brazil: examining the role of educational attainment and differences by gender.

Mateo P Farina, Eric T Klopack, Flavia C D Andrade

Abstract read
In one paragraph

Article in American journal of epidemiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Race/color functional limitation disparities in a "racial democracy": findings among middle-aged and older adults in Brazil.The journals of gerontology. Series B, Psychological sciences and social sciences · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Mateo P FarinaDepartment of Human Development and Family Sciences, Center for Aging and Population Studies, & the Population Research Center, University of Texas at Austin, Austin, TX 78712, United States.ORCID 0000-0002-0765-6550
Eric T KlopackDepartment of Epidemiology and Biostatistics, School of Public Health-Bloomington, Indiana University, Bloomington, IN 47405, United States.ORCID 0000-0002-0019-1332
Flavia C D AndradeSchool of Social Work, University of Illinois Urbana-Champaign, Urbana, IL 61820, United States.ORCID 0000-0002-3856-3816

Funding

RESEARCH TRAINING IN GERONTOLOGYT32AG000037 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI JENNIFER A AILSHIRE, EILEEN M CRIMMINS · 1985 to 2026
$13.2M
Scientific & Technical CoreP2CHD042849 · NICHD · UNIVERSITY OF TEXAS AT AUSTIN · PI MARK D. HAYWARD · 2017 to 2026
$5.2M
Network on Education, Biosocial Pathways, and Dementia across Diverse PopulationsR24AG077433 · NIA · UNIV OF MARYLAND, COLLEGE PARK · PI Sanjay Asthana, Pamela Herd · 2022 to 2026
$3.0M
Epigenetic Mechanisms Linking Lifetime Social and Environmental Exposures to Cognitive AgingR00AG076964 · NIA · UNIVERSITY OF TEXAS AT AUSTIN · PI FARINA, MATTHEW · 2024 to 2024
$249k
Brazilian Ministry of Health: DECIT/SCTIE 404965/2012-1Brazilian Ministry of Health: DECIT/SCTIE TED 28/2017COPID/DECIV/SAPS 20836COPID/DECIV/SAPS 22566COPID/DECIV/SAPS 23700COPID/DECIV/SAPS 25552COPID/DECIV/SAPS 25560COPID/DECIV/SAPS 27510National Institute on Aging of the National Institutes of Health T32AG000037; R00AG076964NIA NIH HHS NIA U01AG009740NIA NIH HHS R00 AG076964NIA NIH HHS R24 AG077433NIA NIH HHS T32 AG000037NICHD NIH HHS P2C HD042849Population Research Center P2CHD042849
6 · The paper itself

Abstract

Early life conditions are associated with later life health. However, research in this area has been based on high-income countries, with limited research in low- and middle-income countries. We examine how childhood conditions are associated with mortality in older adulthood in the United States and Brazil, while evaluating the role of educational attainment and gender differences. Data come from the HRS and ELSI-Brazil. We use structural equation modeling to examine direct and indirect pathways from childhood conditions to mortality in older adulthood for men and women. Results showed substantial differences between Brazil and the United States. Childhood health was associated with increased mortality risk in the United States, not in Brazil. Adverse childhood conditions were associated with increased mortality in Brazil and the United States, but we found a large indirect pathway through educational attainment in the United States. Lastly, we found notable gender differences across both countries, with indirect pathways for United States men and Brazilian women (not their counterparts). Findings point to the malleability of the association of childhood conditions on adulthood mortality risk. Future work should consider how exposures and opportunities combine to influence life course developments of health and aging processes in diverse populations. This article is part of a Special Collection on Cross-National Gerontology.

Indexed as

Adverse Childhood ExperiencesEducational StatusMortalityAgedAged, 80 and overBrazilChildFemaleHumansMaleMiddle AgedSex FactorsUnited Statesearly life origins of healtheducationLMIClong arm of childhoodmortality

Identifiers

PMID40878760
PMCPMC13182659

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.