Evidence map›Paper›PMID 40878644›Full record

ArticleAdvanced biology2025

Illuminating New Frontiers: Exploring the Photosensitizing Potential of Passiflora Species in Combating Methicillin-Resistant Staphylococcus aureus (MRSA) and Their Infection in Senescent Mice.

Caroline Vieira Gonçalves, Maria Poliana Leite Galantini, Igor Pereira Ribeiro Muniz, Paulo Henrique Bispo Lima, Israel Souza Ribeiro, Maria Eduarda Santos de Oliveira, Caio Oliveira Lopes de Magalhães, Maria Elisa Santos Flores, Samara Lopes de Oliveira, Catarina Silva Guimarães and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Caroline Vieira GonçalvesMultidisciplinary Institute of Health, Anísio Teixeira Campus - Federal University of Bahia, Rio de Contas Street, 58, Candeias, Vitória da Conquista, Bahia, CEP: 45.029-094, Brazil.ORCID 0000-0003-0895-1583
Maria Poliana Leite GalantiniMultidisciplinary Institute of Health, Anísio Teixeira Campus - Federal University of Bahia, Rio de Contas Street, 58, Candeias, Vitória da Conquista, Bahia, CEP: 45.029-094, Brazil.
Igor Pereira Ribeiro MunizMultidisciplinary Institute of Health, Anísio Teixeira Campus - Federal University of Bahia, Rio de Contas Street, 58, Candeias, Vitória da Conquista, Bahia, CEP: 45.029-094, Brazil.
Paulo Henrique Bispo LimaMultidisciplinary Institute of Health, Anísio Teixeira Campus - Federal University of Bahia, Rio de Contas Street, 58, Candeias, Vitória da Conquista, Bahia, CEP: 45.029-094, Brazil.
Israel Souza RibeiroPaulo Freire Campus - Federal University of Southern Bahia, Joana Angélica Square, São José, 250, Teixeira de Freitas, Bahia, CEP: 45.988-058, Brazil.
Maria Eduarda Santos de OliveiraMultidisciplinary Institute of Health, Anísio Teixeira Campus - Federal University of Bahia, Rio de Contas Street, 58, Candeias, Vitória da Conquista, Bahia, CEP: 45.029-094, Brazil.
Caio Oliveira Lopes de MagalhãesMultidisciplinary Institute of Health, Anísio Teixeira Campus - Federal University of Bahia, Rio de Contas Street, 58, Candeias, Vitória da Conquista, Bahia, CEP: 45.029-094, Brazil.
Maria Elisa Santos FloresMultidisciplinary Institute of Health, Anísio Teixeira Campus - Federal University of Bahia, Rio de Contas Street, 58, Candeias, Vitória da Conquista, Bahia, CEP: 45.029-094, Brazil.
Samara Lopes de OliveiraMultidisciplinary Institute of Health, Anísio Teixeira Campus - Federal University of Bahia, Rio de Contas Street, 58, Candeias, Vitória da Conquista, Bahia, CEP: 45.029-094, Brazil.
Catarina Silva GuimarãesMultidisciplinary Institute of Health, Anísio Teixeira Campus - Federal University of Bahia, Rio de Contas Street, 58, Candeias, Vitória da Conquista, Bahia, CEP: 45.029-094, Brazil.
Paulinne Moreira LimaMultidisciplinary Institute of Health, Anísio Teixeira Campus - Federal University of Bahia, Rio de Contas Street, 58, Candeias, Vitória da Conquista, Bahia, CEP: 45.029-094, Brazil.
Luísa Carregosa SantosMultidisciplinary Institute of Health, Anísio Teixeira Campus - Federal University of Bahia, Rio de Contas Street, 58, Candeias, Vitória da Conquista, Bahia, CEP: 45.029-094, Brazil.
Daiana Silva LopesMultidisciplinary Institute of Health, Anísio Teixeira Campus - Federal University of Bahia, Rio de Contas Street, 58, Candeias, Vitória da Conquista, Bahia, CEP: 45.029-094, Brazil.
Juliano Geraldo AmaralMultidisciplinary Institute of Health, Anísio Teixeira Campus - Federal University of Bahia, Rio de Contas Street, 58, Candeias, Vitória da Conquista, Bahia, CEP: 45.029-094, Brazil.
Robson Amaro Augusto da SilvaMultidisciplinary Institute of Health, Anísio Teixeira Campus - Federal University of Bahia, Rio de Contas Street, 58, Candeias, Vitória da Conquista, Bahia, CEP: 45.029-094, Brazil.ORCID 0000-0003-1361-1591

Funding

Brazil: Fundação de Amparo à Pesquisa do Estado da BahiaConselho Nacional de Desenvolvimento Científico e Tecnológico 405884/2021-4Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
6 · The paper itself

Abstract

Antimicrobial Photodynamic Therapy (aPDT) has become a potential alternative for treating multidrug-resistant bacterial skin infections, such as those caused by methicillin-resistant Staphylococcus aureus (MRSA), which are at high risk in aging individuals. One of the main components of aPDT is an agent known as a photosensitizer (PS). Some plants with high flavonoid content are reported as PS. In the genus Passiflora, flavonoids are predominant, but their photosensitizing activity has yet to be described. This study investigates the photosensitizing potential of extracts from Passiflora edulis, Passiflora alata, and Passiflora cincinnata. The butanolic fraction of P. cincinnata undergoes in vivo evaluation against intradermal MRSA infection in a senescent murine model (C57BL/6). In vitro assays determine the photoactivatable concentrations and their cytotoxicity. In vivo, MRSA-infected mice are divided into control, P. cincinnata-treated, and aPDT-treated groups. Subsequent assessments include cytokine levels, bacterial load, and cellular infiltrate in the ear. The P. cincinnata-treated group exhibits improved bacterial control, reduced leukocyte infiltration, and less weight loss. The aPDT group demonstrates a unique cytokine correlation profile, featuring more negative correlations among pro-inflammatory cytokines and interleukin-10. P. cincinnata emerges as an effective photosensitizer for aPDT in a senescent model and highlights the potential of underexplored plant-derived photosensitizers.

Indexed as

Methicillin-Resistant Staphylococcus aureusPassifloraPhotochemotherapyPhotosensitizing AgentsPlant ExtractsStaphylococcal InfectionsAnimalsFemaleMiceMice, Inbred C57BLPhotosensitizing AgentsPlant Extractsantimicrobial photodynamic therapymethicillin‐resistant Staphylococcus aureusPassiflora cincinnatasenescence

Identifiers

PMID40878644
PMCPMC12712747

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.