ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025
Centimeter-Scale Self-Assembling Tendon Organoids Drive Tissue Regeneration.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The trial behind it
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Who cites it
5 citing papers in PubMed.
- Self-buoyant cell-spheroid culture programming multi-spheroid assembly.Science advances · 2026Article
- Next-Generation Strategies for Neural Repair and Regeneration: Neural Organoid Transplantation in the CNS.Cell proliferation · 2026Review
- Multitechnological integration advances musculoskeletal regeneration: synergistic progress of organoids, 3D/4D bioprinting, single-cell omics and artificial intelligence.Frontiers in bioengineering and biotechnology · 2026Review
- Immunoengineering in the field of tendon and bone regeneration: immunomodulatory biomaterials, delivery platforms, and preclinical models for chronic diseases.Frontiers in bioengineering and biotechnology · 2026Review
- Centimeter-Scale Self-Assembling Tendon Organoids Drive Tissue Regeneration.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
Corrections and comments
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Authors and funding
17 authors.
Funding
Abstract
As a cell-deficient tissue, the scarcity of endogenous stem cells significantly hampers the regeneration of tissue structure and restoration of motor function following tendon injury. To engineer large-scale transplantable stem cell-derived organoids in vitro would show tremendous potential in regenerative medicine. Here, by optimizing chemical signals and mimicking tendon extracellular matrix, transplantable tendon organoids exceeding 3 cm in human tissue-scale dimensions are ultimately developed. This strategy empowers tendon organoids, with high cellular viability, proliferation, tenogenic phenotype, and remarkable enhancements in extracellular matrix (ECM) production enabled self-assembly. At the single-cell level, the majority cells in tendon organoids successfully achieve precise tendon-specific lineage differentiation in vitro while retaining the exceptional regenerative capacity characteristic of fetal tendons. In a tendon defect model, the organoids increase the retention rate of stem cells by 7.9 times at 4 weeks and initiate the formation of a denser repaired tendon with enhanced mechanical properties. Overall, an efficient construction of centimeter-scale human tendon organoids with superior regenerative potential is achieved, providing a promising strategy for the regenerative medicine.
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Registered trials
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