Evidence map›Paper›PMID 40878467›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Analyses of GWAS and Sub-Threshold Loci Lead to the Discovery of Dendrite Development and Morphology Dysfunction Underlying Schizophrenia Genetic Risk.

Rui Chen, Benjamin Siciliano, Quan Wang, Chongchong Xu, Qiang Wei, Hai Yang, James S Sutcliffe, Yi Jiang, Ying Ji, Chunyu Liu and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Rui ChenDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, 37232, USA.ORCID https://orcid.org/0000-0002-4341-2908
Benjamin SicilianoThe Graduate Program in Molecular and Systems Pharmacology, Laney Graduate School, Emory University, Atlanta, GA, 30322, USA.
Quan WangDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, 37232, USA.
Chongchong XuDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, 30322, USA.
Qiang WeiDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, 37232, USA.
Hai YangDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, 37232, USA.
James S SutcliffeDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, 37232, USA.
Yi JiangDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, 37232, USA.
Ying JiDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, 37232, USA.
Chunyu LiuDepartment of Psychiatry, SUNY Upstate Medical University, Syracuse, NY, 13210, USA.
Feixiong ChengDepartment of Molecular Medicine, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, OH, 44106, USA.
Edwin H CookDepartment of Psychiatry, University of Illinois, Chicago, IL, 60612, USA.
Nancy J CoxVanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, 37232, USA.
Xue ZhongVanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, 37232, USA.
Zhexing WenDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, 30322, USA.
Bingshan LiDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, 37232, USA.ORCID https://orcid.org/0000-0003-2129-168X

Funding

NHGRI Genome Sequencing Program Coordinating CenterU24HG008956 · NHGRI · RUTGERS, THE STATE UNIV OF N.J. · PI BUYSKE, STEVEN G, MATISE, TARA C. · 2016 to 2020
$4.9M
Analysis, Validation and Resource Creation for Genome Sequencing of Complex DiseasesU01HG009086 · NHGRI · VANDERBILT UNIVERSITY · PI COX, NANCY J, LI, BINGSHAN · 2016 to 2020
$4.3M
Genetic variants affect brain gene expression and risks of psychiatric disordersU01MH103340 · NIMH · UPSTATE MEDICAL UNIVERSITY · PI LIU, CHUNYU, RZHETSKY, ANDREY · 2014 to 2017
$4.3M
Drug repositioning for Alzheimer's disease via genetics, electronic health records, and human iPSC modelsR01AG069900 · NIA · VANDERBILT UNIVERSITY · PI LI, BINGSHAN, WEI, WEI-QI · 2021 to 2025
$4.0M
Discovering Biology for Neuropsychiatric Diseases Through Omics Studies on ComorbiditiesR01MH113362 · NIMH · VANDERBILT UNIVERSITY MEDICAL CENTER · PI COX, NANCY J, KNAPIK, ELA W · 2017 to 2021
$3.9M
Towards a better understanding of genetic architecture of Alzheimer's disease with human iPSC modelsR01AG065611 · NIA · EMORY UNIVERSITY · PI LI, BINGSHAN, WEN, ZHEXING · 2020 to 2024
$3.8M
Gene Expression Regulation in Brains of East Asian, African, and European Descent Explains Schizophrenia GWAS in Diverse Populations.R01MH126459 · NIMH · UPSTATE MEDICAL UNIVERSITY · PI Chunyu Liu · 2022 to 2026
$3.7M
Genetics-informed dissection of human brain cell-cell communication in Alzheimer's disease progressionR01AG089717 · NIA · VANDERBILT UNIVERSITY · PI BINGSHAN LI, Zhexing Wen · 2024 to 2026
$2.4M
1/3 High-resolution mapping of cell type-specific DNA (hydroxy)methylation in the human brain during postnatal development and in psychiatric disease.U01MH122591 · NIMH · UPSTATE MEDICAL UNIVERSITY · PI LIU, CHUNYU · 2020 to 2022
$483k
NHGRI NIH HHS U01 HG009086NHGRI NIH HHS U24 HG008956NIA NIH HHS R01 AG065611NIA NIH HHS R01 AG069900NIA NIH HHS R01 AG089717NIH HHS R01AG065611NIH HHS R01AG069900NIH HHS R01AG089717NIH HHS R01MH113362NIH HHS U01HG009086NIH HHS U24HG008956NIMH NIH HHS R01 MH113362NIMH NIH HHS R01 MH126459NIMH NIH HHS U01 MH103340NIMH NIH HHS U01 MH122591
6 · The paper itself

Abstract

Schizophrenia (SCZ) is highly polygenic, and its biological underpinnings remain unclear. In this study, a cost-effective strategy of including sub-threshold GWAS (subGWAS) loci (i.e., 5 × 10

Indexed as

DendritesGenetic Predisposition to DiseaseGenome-Wide Association StudySchizophreniaDCC ReceptorHumansPolymorphism, Single NucleotideDCC Receptordendrite developmentgenetic riskGWASneurodevelopmentalpsychiatric disorderSchizophreniasub‐threshold loci

Identifiers

PMID40878467
PMCPMC12533335

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.