ArticleAnimal bioscience2026
Enhancement of growth performance and health status in heat-stressed growing rabbits using alpha-lipoic acid-loaded chitosan nanoparticles.
Article in Animal bioscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
objectiveThis study investigates the effect of alpha-lipoic acid-loaded chitosan nanoparticles (ALA-CHNPs) on growth performance, feed utilization, and health in heat-stressed growing rabbits.
methodsA total of 125 healthy, 5-week-old rabbits were randomly assigned to five groups of 25. One group served as a thermoneutral control, while the other four groups were subjected to heat stress and received diets supplemented with 0, 100, 200, or 400 mg of ALACHNPs per kilogram, respectively.
resultsDietary supplementation resulted in significant improvements in growth performance, feed conversion ratio, physiological responses, liver weight, and dressing percentage. Supplementation with ALA-CHNPs resulted in a linear reduction in liver enzymes activities, as well as in the levels of total bilirubin, hydrogen peroxide, glutathione, catalase, superoxide dismutase, immunoglobulin G, lysozyme activity, interleukin (IL)-6 and IL-10. No significant differences were observed between the ALA-CHNPs200 and ALACHNPs400 groups (p>0.05). The levels of blood serum total protein, albumin, globulin, total antioxidant capacity, glutathione peroxidase activity, immunoglobulin A and M, and nitric oxide showed a quadratic increase, reaching a peak at ALA-CHNPs doses ranging from 250-300 mg/kg diet. Conversely, the concentrations of triglycerides, cholesterol, glucose, malondialdehyde, interferon-gamma, tumor necrosis factor-alpha, and nuclear factor kappa B exhibited a quadratic decrease, with optimal reductions observed at doses between 250-300 mg/kg diet. Supplementation with ALA-CHNPs reduced liver damage caused by heat stress, restoring normal hepatic morphology. The hydrophobic interactions of ALA with antioxidant enzymes and cytokines contributed to the reduction of heat stress-induced oxidative stress.
conclusionThe inclusion of 250-300 mg ALA-CHNPs/kg diet enhanced growth performance, redox balance, immune function, and inflammatory response in fattened rabbits raised during the summer season.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.