ArticleAnimal bioscience2026
The mechanism of m6A methylation analysis of the transcriptome to regulate the diameter of Alpine Merino wool fiber.
Article in Animal bioscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveWool serves as an important textile raw material, with fiber diameter being a major determinant influencing the economic value and quality of wool products. Investigating the regulatory mechanisms that influence wool fiber diameter is necessary for formulating aimed at improving wool fineness. We used methylationomics to examine the skin tissue of individuals with different fiber diameters, and investigated the regulation mechanisms influencing wool fiber diameter.
methodsIn this study, we analyzed the transcriptome and m6A methylome of skin tissues from individual Alpine Merino sheep, classified into three groups based on wool fiber diameters, to identify key methylated RNAs and explore the role of m6A methylation in regulating this trait.
resultsA total of 54,057 methylated peaks, 4,273 differentially methylated genes, 139 differentially methylated lncRNAs, and 2,992 differentially methylated circRNAs were found in the three comparisons. These gene loci showed enrichment in the Wnt, Notch, and TGF-β signaling pathways, as determined through Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway analyses. RNA correlation analyses revealed key RNAs, such as CACNA1E, FOS, CAMK2B, RNF43, circ-0317, circ-4794, TCONS-00020832, and TCONS-00020845, indicating that hypermethylation may play an important role in affecting wool fiber diameter.
conclusionThe findings elucidate the molecular regulatory mechanisms underlying wool fiber diameter and provide a theoretical foundation for advancements in the wool industry.
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