Evidence map›Paper›PMID 40878447›Full record

ArticleJournal of intellectual disability research : JIDR2025

Contrasting Relationships Between Anxiety and Intolerance of Uncertainty in Cornelia de Lange and Fragile X Syndromes.

Kayla Smith, Victoria Perry, Laura Groves, Joanna Moss, Chris Oliver, Eve Knight, Tom Patterson, Jacqui Rodgers, Jane Waite, Hayley Crawford

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of intellectual disability research : JIDR, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Kayla SmithMental Health and Wellbeing Unit, Division of Health Sciences, Warwick Medical School, University of Warwick, Coventry, UK.ORCID 0000-0002-2208-3367
Victoria PerrySchool of Psychological, Social and Behavioural Sciences, Coventry University, Coventry, UK.
Laura GrovesBirmingham Community Healthcare NHS Foundation Trust, Birmingham, UK.ORCID 0000-0002-8277-3044
Joanna MossCerebra Network for Neurodevelopmental Disorders, University of Birmingham, Birmingham, UK.ORCID 0000-0002-7676-933X
Chris OliverSchool of Psychology, University of Birmingham, Birmingham, UK.ORCID 0000-0001-5217-6209
Eve KnightSchool of Psychological, Social and Behavioural Sciences, Coventry University, Coventry, UK.ORCID 0000-0002-5734-2824
Tom PattersonSchool of Psychological, Social and Behavioural Sciences, Coventry University, Coventry, UK.ORCID 0000-0002-4734-0219
Jacqui RodgersPopulation Health Sciences Institute, Sir James Spence Institute, Newcastle University, Royal Victoria Infirmary, Newcastle Upon Tyne, UK.ORCID 0000-0002-1759-316X
Jane WaiteCerebra Network for Neurodevelopmental Disorders, University of Birmingham, Birmingham, UK.ORCID 0000-0002-8676-3070
Hayley CrawfordMental Health and Wellbeing Unit, Division of Health Sciences, Warwick Medical School, University of Warwick, Coventry, UK.ORCID 0000-0002-1147-7029

Funding

Baily Thomas Charitable FundCerebraCornelia de Lange Syndrome Foundation UK and Ireland
6 · The paper itself

Abstract

backgroundCornelia de Lange syndrome (CdLS) and fragile X syndrome (FXS) are associated with co-occurring autism and anxiety. In autistic people, intolerance of uncertainty (IU) mediates the relationship between autistic characteristics and anxiety, but it is not known whether this relationship is evident in these genetic syndromes. Understanding the relationship between autism, anxiety and IU is essential to informing the theoretical frameworks of anxiety in rare genetic syndromes and improving clinical interventions.

methodSixty participants with CdLS or FXS participated in a questionnaire-based study to examine the association between autistic characteristics, anxiety and IU.

resultsIU mediated the association between autism and anxiety in participants with CdLS but not in participants with FXS.

conclusionsThese results suggest that other factors may contribute to the autism-anxiety relationship in FXS, and highlight the merit of syndrome-specific approaches to the study of anxiety. Recommendations are made for intervention-based research to ameliorate anxiety in CdLS.

Indexed as

AnxietyAutism Spectrum DisorderDe Lange SyndromeFragile X SyndromeAdolescentAdultChildComorbidityFemaleHumansMaleMiddle AgedUncertaintyYoung AdultanxietyautismCornelia de Lange syndromefragile X syndromeintellectual disabilityintolerance of uncertainty

Identifiers

PMID40878447
PMCPMC12580480

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.