Evidence map›Paper›PMID 40878434›Full record

ArticleCancer research and treatment2026

Concept of Depth of Invasion Can Improve Staging Performance in Patients with Resected Distal Cholangiocarcinoma: Validation of the American Joint Committee on Cancer Staging System.

Won-Gun Yun, Yoon Soo Chae, Youngmin Han, Young Jae Cho, Hye-Sol Jung, Wooil Kwon, Joon Seong Park, Haeryoung Kim, Kyoung Bun Lee, Jin-Young Jang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer research and treatment, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Won-Gun YunDepartment of Surgery and Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea.
Yoon Soo ChaeDepartment of Surgery and Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea.
Youngmin HanDepartment of Surgery and Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea.
Young Jae ChoDepartment of Surgery and Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea.
Hye-Sol JungDepartment of Surgery and Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea.
Wooil KwonDepartment of Surgery and Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea.
Joon Seong ParkDepartment of Surgery and Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea.
Haeryoung KimDepartment of Pathology, Seoul National University College of Medicine, Seoul, Korea.
Kyoung Bun LeeDepartment of Pathology, Seoul National University College of Medicine, Seoul, Korea.
Jin-Young JangDepartment of Surgery and Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea. jangjy4@snu.ac.kr.

Funding

Korea Health Industry Development InstituteMinistry of Health and Welfare HI23C1591
6 · The paper itself

Abstract

Purpose: The American Joint Committee on Cancer (AJCC) staging system for distal cholangiocarcinoma (dCC) has evolved significantly. However, the prognostic correlation of the newly proposed staging system remains unclear. Therefore, we aimed to compare the staging performance between AJCC 7th and 8th editions for dCC. Materials and Methods: We reviewed pathological slides of consecutive patients who underwent resection for dCC between 2000 and 2022. According to the AJCC 8th edition, depth of invasion was defined as the distance from the basement membrane of adjacent normal or dysplastic epithelium to the deepest tumor invasion. We analyzed changes in the T category from the AJCC 7th to 8th edition and assessed overall survival and recurrence based on these staging systems. Results: Among 428 patients, application of the 8th edition resulted in down-staging of 272 (63.6%) patients and up-staging of only 13 (3.0%). Lymph node metastases were identified in 150 (35.1%) patients, with 29 (6.8%) having ≥ 4 metastatic nodes. The C-indices for overall survival and recurrence are 0.557 and 0.569 for the T category of the AJCC 7th edition, and 0.606 and 0.631 for that of the AJCC 8th edition (95% confidence interval for delta, 0.005 to 0.092 for survival, 0.023 to 0.100 for recurrence). Additionally, the T category of the 8th edition correlated more strongly with lymph node metastases than that of the 7th edition. Conclusion: In dCC, the T category of the AJCC 8th edition demonstrates improved prognostic correlation and better alignment with lymph node metastases compared to that of the 7th edition.

Indexed as

Bile Duct NeoplasmsCholangiocarcinomaNeoplasm StagingAdultAgedFemaleHumansLymphatic MetastasisMaleMiddle AgedNeoplasm InvasivenessNeoplasm Recurrence, LocalPrognosisCholangiocarcinomaNeoplasm invasivenessNeoplasm stagingPrognosisRecurrence

Identifiers

PMID40878434
PMCPMC13680061

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.