Evidence map›Paper›PMID 40878403›Full record

ArticleAllergy2025

Myeloid cAMP Reduction Shifts Rhinovirus-Induced Airway Inflammation From Neutrophilic to Eosinophilic by Suppressing M1-Interstitial Macrophages.

Seong Ok Park, Erdenebileg Uyangaa, Hyo Jin Kim, Hee Won Byeon, Jin Young Choi, Koanhoi Kim, Jihyung Lee, Samuel Bertin, Eyal Raz, Seong Kug Eo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Allergy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Seong Ok ParkCollege of Veterinary Medicine, Biosafety Research Institute and Core Facility Center for Zoonosis Research, Jeonbuk National University, Iksan, Republic of Korea.
Erdenebileg UyangaaCollege of Veterinary Medicine, Biosafety Research Institute and Core Facility Center for Zoonosis Research, Jeonbuk National University, Iksan, Republic of Korea.
Hyo Jin KimCollege of Veterinary Medicine, Biosafety Research Institute and Core Facility Center for Zoonosis Research, Jeonbuk National University, Iksan, Republic of Korea.
Hee Won ByeonCollege of Veterinary Medicine, Biosafety Research Institute and Core Facility Center for Zoonosis Research, Jeonbuk National University, Iksan, Republic of Korea.
Jin Young ChoiCollege of Veterinary Medicine, Biosafety Research Institute and Core Facility Center for Zoonosis Research, Jeonbuk National University, Iksan, Republic of Korea.
Koanhoi KimDepartment of Pharmacology, School of Medicine, Pusan National University, Busan, Republic of Korea.
Jihyung LeeDivision of Rheumatology, Allergy & Immunology, Department of Medicine, University of California, San Diego, La Jolla, California, USA.
Samuel BertinDivision of Rheumatology, Allergy & Immunology, Department of Medicine, University of California, San Diego, La Jolla, California, USA.
Eyal RazDivision of Rheumatology, Allergy & Immunology, Department of Medicine, University of California, San Diego, La Jolla, California, USA.
Seong Kug EoCollege of Veterinary Medicine, Biosafety Research Institute and Core Facility Center for Zoonosis Research, Jeonbuk National University, Iksan, Republic of Korea.

Funding

Korea Basic Science Institute 2021R1A6C101C369Korea Health Industry Development Institute HI22C0591National Research Foundation of Korea 2019R1A6A1A03033084National Research Foundation of Korea RS-2025-00513722
6 · The paper itself

Abstract

backgroundAsthma exacerbations caused by human rhinovirus (hRV) infection are characterized by airway neutrophilia and reduced corticosteroid response, leading to significant healthcare costs and lung function impairment. The Gαs subunit of the trimeric G protein regulates immunopathological conditions by modulating cAMP levels. We aimed to investigate the impact of myeloid cAMP levels on neutrophil-dominated asthma exacerbation caused by hRV infection.

methodsWe generated mice with myeloid cell-specific deletion of the Gαs subunit by targeting the LysM gene, leading to a specific reduction of cAMP in myeloid cells. Neutrophilic asthma exacerbation was induced by hRV infection during allergen challenge, and cytokine production in BALF and lung tissue was assessed, along with histological examinations.

resultsMyeloid Gαs ablation was found to shift airway inflammation from a neutrophilic to an eosinophilic phenotype during hRV-induced asthma exacerbation. This change led to mucus hypersecretion and Th2-type inflammation, and enhanced CD4

conclusionsThese results highlight the essential role of macrophage cAMP in steroid-resistant, neutrophil-dominant airway inflammation during hRV-induced asthma exacerbation.

Indexed as

AsthmaCyclic AMPEosinophilsMacrophagesMyeloid CellsNeutrophilsPicornaviridae InfectionsRhinovirusAnimalsCytokinesDisease Models, AnimalHumansInflammationMiceCyclic AMPCytokinesasthma exacerbationcAMPhuman rhinovirusinflammasomemacrophage polarization

Identifiers

PMID40878403
PMCPMC12590349

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.