Evidence map›Paper›PMID 40878377›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

A Multifunctional Molecular Probe for Multimodal Imaging-Guided Potent Photothermal/Photodynamic Therapy of Endometriosis.

Qiyu Zhong, Shuguang Yang, Xiao Li, Zhuang Jin, Jianyu Ma, Zhouzhou Liao, Jinbo Li, Bo Li, Xintao Shuai, Shuqin Chen

Abstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Qiyu ZhongDepartment of Gynecology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510655, China.
Shuguang YangDepartment of Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai, 200025, China.
Xiao LiDepartment of Gynecology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510655, China.
Zhuang JinDepartment of Gynecology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510655, China.
Jianyu MaDepartment of Gynecology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510655, China.
Zhouzhou LiaoDepartment of Gynecology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510655, China.
Jinbo LiDepartment of Gynecology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510655, China.
Bo LiGuangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology, the NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou, 511436, China.ORCID https://orcid.org/0000-0002-5575-3582
Xintao ShuaiNanomedicine Research Center, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510630, China.ORCID https://orcid.org/0000-0003-4271-0310
Shuqin ChenDepartment of Gynecology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510655, China.ORCID https://orcid.org/0000-0002-8260-5809

Funding

Basic and Applied Basic Research Foundation of Guangdong Province 2024A1515140024National Natural Science Foundation of China 82302359Natural Science Foundation of Guangdong Province 2023A1515011822Scientific and Technological Planning Project of Guangzhou City 2023A03J0215
6 · The paper itself

Abstract

Multifunctional small-molecule theranostic agents hold significant clinical potential for non-invasive endometriosis (EMS) management. Current EMS treatment faces challenges due to imprecise lesion localization and therapy-associated side effects. Herein, an integrated theranostic probe, cRGDyK-ICG-Lys-DTPA@Gd (cRGD-ILD), designed for concurrent precise lesion localization and targeted phototherapy in EMS, is developed. This molecular probe integrates three key functional components: the DTPA@Gd complex provides contrast for magnetic resonance imaging, the ICG fragment enables fluorescence imaging and photoacoustic imaging while serving as the phototherapeutic agent, and the cRGD peptide targets integrin α

Indexed as

EndometriosisMolecular ProbesMultimodal ImagingPhotochemotherapyPhotothermal TherapyAnimalsFemaleHumansMiceRatsMolecular Probesendometriosismultimodal imagingphotodynamic therapyphotothermal therapysmall molecular probe

Identifiers

PMID40878377
PMCPMC12631912

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.