ArticleSmall (Weinheim an der Bergstrasse, Germany)2025
Bioassembly of Myoblast Spheroids in Electrofibrillated Scaffolds for 3D Muscle Tissue Biofabrication.
Article in Small (Weinheim an der Bergstrasse, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed.
- Muscle-fiber-inspired nanofibrillar microbundles induce myogenic differentiation in human adipose-derived stem cells.Bioactive materials · 2026Article
- A high-throughput 3D conjunctival spheroid model for standardized in vitro testing.Scientific reports · 2026Article
- Nanotechnology-mediated strategies for skeletal muscle repair and regeneration: targeted intervention, functional remodeling, and translational challenges.Journal of nanobiotechnology · 2026Review
- Bioprinting Organs-Science or Fiction?-A Review From Students to Students.Advanced healthcare materials · 2026Review
- Giving It a Twist: One-Step Fabrication of Aligned Biomimetic Yarn Scaffolds via Rotational Melt Electrofibrillation.Advanced healthcare materials · 2026Article
- Fibrillar Bundles as Fibrous Filler Materials for Attaining Cell Anisotropy in Bioprinting.Advanced healthcare materials · 2026Article
- Bioassembly of Myoblast Spheroids in Electrofibrillated Scaffolds for 3D Muscle Tissue Biofabrication.Small (Weinheim an der Bergstrasse, Germany) · 2025Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
One of the key challenges in tissue engineering is recreating the extracellular matrix (ECM), which is essential for cell function, especially in anisotropic tissues like muscle, where tissue morphology dictates contraction and motion. The recently developed method of melt electrofibrillation offers a promising platform for producing highly aligned nanofibrillar scaffolds that mimic collagen. These scaffolds are created by melt electrowriting a blend of polycaprolactone (PCL) and polyvinyl acetate (PVAc), which are precisely printed in a box geometry. After washing out the PVAc, aligned nano-scaled PCL fibrils remain. These fibers provide extracellular matrix-like cues for cells to mature, encouraging them to align and interact with the structure. This study showcases the application of C2C12 muscle cells, which are assembled into spheroids and seeded on the scaffolds. Over 21 days, the cells align along the fibrils, colonize the scaffold, and, when exposed to differentiation media, begin forming early-stage myotubes and express myogenic factors, such as Myogenin. This demonstrates that the synthetic matrix is a useful tool for studying the interaction of aligned 3D matrices in muscle tissue differentiation.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.