ReviewMolecular pain2025
EXPRESS: Honokiol and analgesia: a mechanistic review on the current capacities and challenges.
Review in Molecular pain, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
3 authors.
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Abstract
Pain is an unfavorable subjective sensation influencing 20% of the public population, giving rise to substantial health and economic issues. Several categories of pain, such as acute and chronic pain, have been determined according to factors like pathophysiological mechanism, etiology, and anatomical locations. The current analgesic drugs are the cornerstone of pain management; however, some challenges, such as short-term relief and concerns about addiction, dependence, and side effects, warrant alternative choices for pain alleviation. In the recent decade, the importance of polyphenolic compounds, particularly honokiol, has increased due to their diverse therapeutic and biological features like anti-cancer, anti-inflammatory, anti-oxidative, anti-bacterial, anti-viral, and immune regulatory properties. Also, some documents have accentuated the striking role of honokiol in exerting analgesic effects in conditions such as inflammatory pain, neuropathic pain, and gouty arthritis. Ergo, the current literature review aimed to discuss the analgesic potential of honokiol in the mentioned conditions with a mechanistic insight.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.