SynthesisThe Indian journal of medical research2025
Prognostic significance of the kinesin superfamily in breast cancer: A systematic review & meta-analysis.
Synthesis in The Indian journal of medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Stable overexpression of Nup88 enhances HeLa cell migration through independent regulation of Kif7 and Gli1.Oncology reports · 2026Article
- KIF14 in cancer biology: implications for diagnosis and therapy.Clinical & experimental metastasis · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background & objectives Kinesin superfamily proteins (KIFs), essential motor proteins involved in processes like mitosis and intracellular transport, have emerged as critical players in breast cancer (BC) progression. Recent studies highlight their potential as prognostic biomarkers and therapeutic targets. This research explores the association between the expression of KIFs and survival outcomes, including overall survival (OS), recurrence-free survival (RFS), and distant metastasis-free survival (DMFS). Methods In this study, we carried out a meta-analysis as per the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. A thorough literature search was conducted using the PubMed and ScienceDirect databases, covering the period from June 1996 to October 2024. Hazard ratios (HRs) and their corresponding 95 per cent confidence intervals (CIs) were extracted from eligible studies and analysed using the RevMan software. Results Initially, we screened 220 articles for this systematic review, from which 11 studies met the inclusion criteria for the meta-analysis. In our analysis, we have observed that elevated KIFs levels were associated with poor OS (HR=1.77 with 95% CI=1.58-1.98 and P<0.00001), RFS (HR=1.40, 95% CI=1.31-1.49, P<0.00001), and DMFS (HR=1.72, 95% CI=1.49-1.99, P<0.00001). These findings suggest that increased expression of kinesin family members contributes to reduced survival rates and increases the risks of recurrence and metastasis in BC patients. Interpretation & conclusions Our study highlights the potential of kinensin family members as prognostic biomarkers for BC progression, providing insights that may help in clinical decision-making and patient management.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.