Evidence map›Paper›PMID 40878327›Full record

ArticleThe Indian journal of medical research2025

Expression of circulating p38 inhibited cutaneous squamous cell carcinoma-associated long non-coding RNA in rheumatoid arthritis: A descriptive study.

Vinit Sharma, Aditya Aggarwal, Justin Jacob, Mayank Sharma, Shivangani Lohani, Ankita Semwal, Ankita Arora, Sakshi Bansal, Anjali Aggarwal

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Indian journal of medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Vinit SharmaDepartment of Anatomy, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Aditya AggarwalDepartment of Orthopaedics, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Justin JacobDepartment of Anatomy, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Mayank SharmaDepartment of Anatomy, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Shivangani LohaniDepartment of Anatomy, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Ankita SemwalDepartment of Anatomy, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Ankita AroraDepartment of Anatomy, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Sakshi BansalDepartment of Anatomy, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Anjali AggarwalDepartment of Anatomy, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background & objectives Rheumatoid arthritis (RA) is a chronic inflammatory disease characterised by joint destruction. Long non-coding RNAs (lncRNAs) have emerged as key regulators in RA pathogenesis. This study explores the serum expression of p38-inhibited cutaneous squamous cell carcinoma-associated lncRNA (PICSAR lncRNA) as a potential non-invasive biomarker for RA. Methods PICSAR lncRNA expression was measured in serum samples from 36 individuals with RA and 20 healthy individuals using qRT-PCR over a 24 h time course. Correlation analyses with demographic and biochemical parameters, American College of Rheumatology (ACR) scores, and ROC analysis were conducted to evaluate the diagnostic potential of PICSAR lncRNA. Results We observed significant upregulation of PICSAR lncRNA in individuals with RA at 0 h (448.9±358.6, P=0.0059) and 6 h (202.0±121.2, P=0.0005) compared to healthy individuals, with stable levels maintained up to 24 h. The ROC analysis yielded a substantial AUC value of 0.74 for PICSAR lncRNA in individuals with RA. In females with RA, PICSAR lncRNA levels showed a positive correlation with ACR scores and a negative correlation with age. Interpretation & conclusions PICSAR lncRNA is implicated in RA pathogenesis and may serve as a potential non-invasive diagnostic biomarker for RA.

Indexed as

Arthritis, RheumatoidCarcinoma, Squamous Cellp38 Mitogen-Activated Protein KinasesRNA, Long NoncodingSkin NeoplasmsAdultAgedBiomarkersBiomarkers, TumorFemaleHumansMaleMiddle AgedBiomarkersBiomarkers, Tumorp38 Mitogen-Activated Protein KinasesRNA, Long NoncodingDiagnosisnon-invasive biomarkerPICSAR long non-coding RNArheumatoid arthritis

Identifiers

PMID40878327
PMCPMC12550381

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.