ArticleThe world journal of men's health2026
Efficacy and Safety of Coenzyme Q10 in Idiopathic Male Infertility: A Systematic Review and Meta-Analysis of Randomized Trials.
Article in The world journal of men's health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- Oxidative Stress and Male Infertility: A Critical Analysis of Current Diagnostic and Therapeutic Methods.Antioxidants (Basel, Switzerland) · 2026Review
- Impact of antioxidant and micronutrient intake on varicocele-associated infertility: a retrospective analysis.Frontiers in nutrition · 2026Article
- Heat shock proteins in male infertility: recent advances and clinical implications.Frontiers in cell and developmental biology · 2026Review
- A Randomized, Double-Blind, Placebo-Controlled Trial Comparing the Effects of Commercially Available Ubiquinone, Ubiquinol, and Geranylgeraniol Dietary Supplements on Plasma CoQ10 Concentrations.Journal of nutrition and metabolism · 2026Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeDespite numerous studies on coenzyme Q10 (CoQ10) as a treatment for idiopathic male infertility (IMI), clear clinical guidance remains lacking. This systematic review and meta-analysis (SRMA) aimed to evaluate the efficacy of CoQ10 and determine the optimal dose, formulation, and treatment duration compared to placebo or other therapies. MATERIALS AND
methodsWe searched PubMed, Science Direct, and Cochrane Library using relevant keywords to identify studies assessing CoQ10's effects on sperm parameters, seminal CoQ10 levels, and clinical pregnancy rates in men with IMI. Study quality was assessed using the Revised Cochrane Risk of Bias tool (RoB2), and meta-analyses were conducted using Review Manager 5.4. The protocol was registered in PROSPERO (CRD42024513515).
resultsNine studies comprising 781 participants (430 treatment, 351 control) met the inclusion criteria. CoQ10 supplementation significantly improved sperm concentration (mean differences [MD]: 10.22×10⁶/mL [3.51-16.93], p=0.003), seminal volume (MD: 0.17 mL [0.03-0.31], p=0.02), total sperm motility (MD: 4.95% [1.15-8.75], p=0.01), and seminal CoQ10 levels (MD: 37.04 ng/ml [31.24-42.84], p<0.001). It also significantly increased clinical pregnancy odds (odds ratio: 6.02 [1.97-18.41], p=0.002). Subgroup analysis showed that treatment duration >3 months significantly improved sperm morphology (p<0.05). Three studies reported no adverse effects, while one noted mild, transient side effects.
conclusionsCoQ10 supplementation in men with IMI significantly improves semen quality, seminal CoQ10 levels, and clinical pregnancy rates, particularly when used for over 3 months. CoQ10 therapy in infertile men with IMI is generally safe, whether used alone or in combination with other antioxidants.
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