Evidence map›Paper›PMID 40878011›Full record

ArticleOrganic letters2025

Chemoselective Benzylic C-H Deuteration Using Deuterium Gas.

Jie-Lun Yan, Guangrong Meng, Daniel A Strassfeld, Michael N Donohoe, Kap-Sun Yeung, Bryan J Simmons, T G Murali Dhar, Jennifer X Qiao, Jin-Quan Yu

Abstract read
In one paragraph

Article in Organic letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Water-Dispersible Ruthenium Nanocatalyst for Carbonyl Reduction With DAngewandte Chemie (International ed. in English) · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jie-Lun YanDepartment of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States.ORCID 0000-0003-3340-2746
Guangrong MengDepartment of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States.ORCID 0000-0002-3023-0654
Daniel A StrassfeldDepartment of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States.ORCID 0000-0003-3598-0793
Michael N DonohoeDepartment of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States.
Kap-Sun YeungResearch & Development, Bristol Myers Squibb, 250 Water Street, Cambridge, Massachusetts 02141, United States.ORCID 0000-0003-3995-6555
Bryan J SimmonsResearch & Development, Bristol Myers Squibb, 10300 Campus Point Drive, San Diego, California 92121, United States.ORCID 0000-0003-2745-2042
T G Murali DharResearch & Development, Bristol Myers Squibb, Route 206 and Provinceline Road, Princeton, New Jersey 08543, United States.ORCID 0000-0003-0738-1021
Jennifer X QiaoResearch & Development, Bristol Myers Squibb, 250 Water Street, Cambridge, Massachusetts 02141, United States.ORCID 0000-0002-6685-2092
Jin-Quan YuDepartment of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States.ORCID 0000-0003-3560-5774

Funding

Ligand-promoted Enantioselective C-H Activation ReactionsR01GM084019 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI YU, JIN-QUAN · 2008 to 2024
$9.5M
Pd-Catalyzed C(sp3)-H Functionalizations Directed by Free Alcohols and Boc-Protected AminesF32GM143921 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI STRASSFELD, DANIEL AARON · 2022 to 2023
$137k
NIGMS NIH HHS F32 GM143921NIGMS NIH HHS R01 GM084019
6 · The paper itself

Abstract

Chemoselective incorporation of hydrogen isotopes is a useful tool for drug discovery and mechanistic investigation. While late-stage C-H functionalization via hydrogen isotope exchange (HIE) offers a straightforward route to isotopically labeled compounds, existing methods often use deuterated solvents which are not feasible for tritium labeling. Hence, direct use of simple deuterium gas for isotopic labeling is highly desirable. Herein, we report a palladium-catalyzed protocol for benzylic C-H deuteration using deuterium gas as the isotope donor and

Identifiers

PMID40878011
PMCPMC12614230

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.