ArticleInfectious diseases of poverty2025
Biological characteristics and epidemiological insights into the zoonotic potential of Colpodella spp.: a scoping review.
Article in Infectious diseases of poverty, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Establishment and application of a multiplex qPCR panel for multi-host surveillance of tick-Borne pathogens.Emerging microbes & infections · 2026Article
- Origins and Molecular Features of a Chimeric Type-P4A ATPase-Guanylate Cyclase from Stramenopiles and Alveolates.International journal of molecular sciences · 2026Article
- Colpodellosis: IsPathogens (Basel, Switzerland) · 2026Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundColpodella species are classified within the domain Eukaryota, specifically under the order Colpodellida, family Colpodellaceae, and genus Colpodella, which are close relative of the phylum Apicomplexa. These organisms are unicellular, predatory flagellates. In recent years, their frequent detection in animal tissues, vector insect samples, and particularly in human has garnered significant attention as an emerging zoonotic threat. This review is to scope the biological characteristics and epidemiological features of Colpodella species.
methodsThe PubMed, Web of Science, and China National Knowledge Infrastructure databases were searched to identify studies in English or Chinese published before 4 February 2025. We searched for Colpodella-related nucleotide sequences released in the GenBank before 31 December, 2024. The literature and sequences were selected based on predefined inclusion criteria. We extracted the characteristics of Colpodella spp. from included articles and performed a phylogenetic analysis based on the included sequences.
resultsThirty-seven records and 83 sequences were included in the study, respectively. Colpodella spp. currently comprise only two formally named species, alongside at least 11 species uncultured or unnamed in GenBank. Their life cycle includes trophozoite and cyst stages, with nutrient acquisition mediated by myzocytosis. These organisms display structural and protein similarities in their apical complexes to apicomplexan protozoa, yet with distinct differences. They are currently found in a wide range of hosts, including humans, livestock, pets, wildlife and vectors, across multiple continents, including Europe, Asia, Africa, and the Americas. Phylogenetic analyses reveal that Colpodella spp. exhibit significant genetic diversity and can be divided into seven clades, each characterized by distinct host ranges and regional distributions, and three clades posed pathogenic potential and significant risk of human infection.
conclusionsThis study systematically elucidates the broad host/vector range, genetic diversity and public health implications of Colpodella species based on comprehensive integrated genomic and epidemiological analyses. We recommend establishing active surveillance networks using clade-specific molecular markers for hosts and vectors in high-risk regions, incorporating Colpodella screening into routine diagnostics for fever cases of unknown origin with anaemia, prioritizing studies on isolation and cultivation, biological characteristics, and clade-specific in vitro invasion assays to elucidate the pathogenic mechanisms.
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