Evidence map›Paper›PMID 40877976›Full record

ArticleStem cell research & therapy2025

Menstrual blood-derived endometrial stem cells ameliorate neuroinflammation and apoptosis through JAK2/STAT3 signaling pathway in NPC1 mutant cell and mice.

Lihong Guan, Keli Xu, Minlin Yang, Yangyang Li, Xiaoying Li, Han Li, Ciqing Yang, Liang Qiao, Yanli Liu, Zisen Jia and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cell research & therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Lihong Guan *Stem Cell and Biotherapy Technology Research Center of Henan, School of Life Science and Technology, Xinxiang Medical University, Xinxiang, 453003, Henan, China.
Keli Xu *Stem Cell and Biotherapy Technology Research Center of Henan, School of Life Science and Technology, Xinxiang Medical University, Xinxiang, 453003, Henan, China.
Minlin Yang *Stem Cell and Biotherapy Technology Research Center of Henan, School of Life Science and Technology, Xinxiang Medical University, Xinxiang, 453003, Henan, China.
Yangyang LiStem Cell and Biotherapy Technology Research Center of Henan, School of Life Science and Technology, Xinxiang Medical University, Xinxiang, 453003, Henan, China.
Xiaoying LiStem Cell and Biotherapy Technology Research Center of Henan, School of Life Science and Technology, Xinxiang Medical University, Xinxiang, 453003, Henan, China.
Han LiStem Cell and Biotherapy Technology Research Center of Henan, School of Life Science and Technology, Xinxiang Medical University, Xinxiang, 453003, Henan, China.
Ciqing YangStem Cell and Biotherapy Technology Research Center of Henan, School of Life Science and Technology, Xinxiang Medical University, Xinxiang, 453003, Henan, China.
Liang QiaoStem Cell and Biotherapy Technology Research Center of Henan, School of Life Science and Technology, Xinxiang Medical University, Xinxiang, 453003, Henan, China.
Yanli LiuStem Cell and Biotherapy Technology Research Center of Henan, School of Life Science and Technology, Xinxiang Medical University, Xinxiang, 453003, Henan, China.
Zisen JiaStem Cell and Biotherapy Technology Research Center of Henan, School of Life Science and Technology, Xinxiang Medical University, Xinxiang, 453003, Henan, China.
Jinghui WeiStem Cell and Biotherapy Technology Research Center of Henan, School of Life Science and Technology, Xinxiang Medical University, Xinxiang, 453003, Henan, China.
Fen YangHenan Joint International Research Laboratory of Stem Cell Medicine, School of Medical Engineering, Xinxiang Medical University, Xinxiang, 453003, Henan, China.
Juntang LinStem Cell and Biotherapy Technology Research Center of Henan, School of Life Science and Technology, Xinxiang Medical University, Xinxiang, 453003, Henan, China. linjtlin@126.com.ORCID http://orcid.org/0000-0001-9300-1771

Funding

Henan Province Foundation for University Key Teacher 2024GGJS088Henan Province Joint Fund for Science and Technology Research and Development 235101610002Joint project of Henan Medical Science and Technology Research Program LHGJ20230888Key Technologies R&D Program of Henan Province 242102310010National Natural Science Foundation of China 81801127Natural Science Foundation of Henan Province 242300421199Natural Science Foundation of Henan Province 252300421395Science and Technology Innovation Talents in Universities of Henan Province 25HASTIT053
6 · The paper itself

Abstract

backgroundNiemann-Pick disease type C1 (NPC1) is caused by NPC1 gene mutations, resulting in Purkinje cell degeneration and death, glial cell activation, and progressive neurodegeneration. Menstrual blood-derived endometrial stem cells (MenSCs) have been explored as a promising tool for treating neurodegenerative diseases due to their wide range of sources, non-invasive nature, and regular collection methods.

objectivesThis study aims to investigate whether MenSCs can improve neuroinflammation and apoptosis in NPC1 mutant cell (Npc1

methodsMenSCs were transplanted into the 4-week-old Npc1

resultsMenSCs transplantation could slow down the rate of weight loss and improve motor coordination in Npc1

conclusionOur study demonstrate that MenSCs ameliorate neuroinflammation and apoptosis in NPC1 mutant cell and mice through JAK2/STAT3 signaling pathway.

Indexed as

EndometriumJanus Kinase 2Neuroinflammatory DiseasesNiemann-Pick C1 ProteinNiemann-Pick Disease, Type CSTAT3 Transcription FactorStem CellsAnimalsApoptosisFemaleHumansMiceMice, KnockoutSignal TransductionJak2 protein, mouseJanus Kinase 2Niemann-Pick C1 ProteinNpc1 protein, mouseStat3 protein, mouseSTAT3 Transcription FactorMesenchymal stem cellsNeuroinflammationNiemann-Pick disease type C1Purkinje cellUnesterified cholesterol

Identifiers

PMID40877976
PMCPMC12395760

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.