ArticleStem cell research & therapy2025
Antimicrobial peptide PK34 modification enhances the antibacterial and anti-inflammatory effects of bone-derived mesenchymal stem cells in Mycobacterium tuberculosis infection.
Article in Stem cell research & therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Secreted Peptidome Profiling of Human Dental Pulp Stem Cells-Conditioned Medium During Odontogenic Differentiation.International dental journal · 2026Article
- Review
- Stem cell-based therapies for silicosis: mechanisms, sources, clinical translation, and emerging strategies.Frontiers in immunology · 2026Review
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Authors and funding
13 authors.
Funding
Abstract
backgroundNew therapeutic strategies are needed to treat tuberculosis (TB). The antimicrobial peptide PK34 has a good ability to clear Mycobacterium tuberculosis (Mtb) and is not prone to drug resistance and adverse reactions. Mesenchymal stem cells (MSCs) can also be used as an adjunctive therapy for the treatment of TB. However, there have been no studies combining the two for the treatment of Mtb infection.
methodsWe aimed to construct bone-derived mesenchymal stem cells secreting the antimicrobial peptide PK34 (named Plent-PK34-BMSCs) and to investigate their roles in both in vitro and in vivo Mtb H37Rv infection models.
resultsWe successfully constructed Plent-PK34-BMSCs that secrete and express the antimicrobial peptide PK34, and demonstrated that PK34 modified MSCs significantly enhanced their in vitro and in vivo antibacterial ability and cytoprotective effects. The cytokine results showed that Plent-PK34-BMSCs increased the levels of anti-inflammatory factors IL-4 and IL-10 in the cell supernatant, decreased the levels of pro-inflammatory factors IL-6 in the serum of the mice. In addition, lung tissue analysis results showed that mice treated with Plent-PK34-BMSCs had reduced infiltration and congestion of inflammatory cells in lung tissue, significantly reduced lung injury, and exhibited better preservation of lung structure.
conclusionsPK34 modification enhanced the therapeutic efficacy of MSCs in Mtb infection models, and Plent-PK34-BMSCs transplantation has the potential to treat TB.
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