Evidence map›Paper›PMID 40877880›Full record

ArticleJournal of nanobiotechnology2025

Genetically engineered Magnesium/Manganese nanoparticles for cancer radioimmunotherapy.

Jicheng Wu, Yangtao Xu, Yunjing Zhang, Kaixin Zhang, Jing Zhang, Yiming Guo, Peng She, Lang Rao, Ximing Xu

Abstract read
In one paragraph

Article in Journal of nanobiotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Review
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jicheng Wu *Cancer Center, Renmin Hospital of Wuhan University, Wuhan, 430060, China.
Yangtao Xu *Cancer Center, Renmin Hospital of Wuhan University, Wuhan, 430060, China.
Yunjing Zhang *Department of Ultrasound, Renmin Hospital of Wuhan University, Wuhan, 430060, China.
Kaixin ZhangZhejiang Provincial Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, China.
Jing ZhangInstitute of Chemical Biology, Shenzhen Bay Laboratory, Shenzhen, 518132, China.
Yiming GuoInstitute of Chemical Biology, Shenzhen Bay Laboratory, Shenzhen, 518132, China.
Peng SheDepartment of Orthopedics, The Seventh Affiliated Hospital of Sun Yat-Sen University, Shenzhen, 518000, China. shep@mail.sysu.edu.cn.
Lang RaoCancer Center, Renmin Hospital of Wuhan University, Wuhan, 430060, China. lrao@szbl.ac.cn.
Ximing XuCancer Center, Renmin Hospital of Wuhan University, Wuhan, 430060, China. doctorxu120@whu.edu.cn.

Funding

Fundamental Research Funds for Central Universities of the Central South University 2042023kf0037National Natural Science Foundation of China 82372106 and 82222035Open Project of Hubei Key Laboratory 2023KFZZ021 and 2023KFZZ029Shenzhen Medical Research Fund B2302041the Natural Science Foundation of Hubei Province 2024AFB129
6 · The paper itself

Abstract

Radiotherapy (RT) has great potential on activating antitumor immunity for combination therapy, yet this effect is limited by immunosuppressive tumor microenvironment (TME) and the potential toxicity in immune cells from high-dose radiation. Herein, we developed engineered nanoparticles (NPs) (CVs@MgMn) composed of genetically edited cellular vesicles (CVs), MnO

Indexed as

MagnesiumManganeseMetal NanoparticlesNanoparticlesNeoplasmsRadioimmunotherapyAnimalsCell Line, TumorFemaleHumansManganese CompoundsMiceMice, Inbred C57BLOxidesTumor MicroenvironmentMagnesiumManganeseManganese CompoundsOxidesBiomimetic nanoparticleCancer immunotherapy, RadiotherapycGAS-STINGImmune checkpoint blockade

Identifiers

PMID40877880
PMCPMC12395731

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.