ArticleBMC psychiatry2025
Amygdala volume abnormalities and cognitive impairment in major depressive disorder and bipolar disorder II.
Article in BMC psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- The Regulatory Potential of Long Non-Coding RNAs in Bipolar Disorder.International journal of molecular sciences · 2026Review
- Cognitive impairment based on computerized testing among patients with major depressive disorder after remission.Frontiers in human neuroscience · 2026Article
- Assessing health, wellbeing, and working life impacts of a 4-day week: a multimodal protocol.Frontiers in psychology · 2026Article
- Editorial: Neuroimaging in psychiatry 2023: mood disorders.Frontiers in psychiatry · 2025Article
- Factors associated with sleep disorders in elderly patients with Parkinson's disease and cognitive impairment and the nomogram model development.Frontiers in aging neuroscience · 2025Article
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Abstract
backgroundThe amygdala, as a crucial brain region, plays a key role in processing emotions and cognitive information. Given that patients with major depressive disorder (MDD) and bipolar disorder II (BD II) experience cognitive impairments, accurate diagnosis becomes a vital research focus. Consequently, we conducted an in-depth investigation into the relationship between the static volume of the amygdala and cognitive functions, aiming to provide valuable insights for future research in this field.
methodsWe collected a total of 42 treatment-naive MDD patients, 38 BD II patients, and 46 healthy controls (HC) from the Third People's Hospital of Foshan. Using magnetic resonance imaging (MRI) and an automated segmentation tool, we extracted the structural volumes of the amygdala. Pearson correlation analyses were performed with scores from the 17-item Hamilton Depression Rating Scale (HAMD), the Hamilton Anxiety Rating Scale (HAMA), and the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). Finally, we compared clinical data, as well as volume changes in the amygdala, among MDD patients, BD patients, and HC.
resultsIn terms of depression scores, MDD individuals experience more severe emotional distress than those with BD. Both MDD and BD II patients show significantly higher anxiety levels compared to the HC. BD II is linked to widespread cognitive deficits, indicating poorer cognitive performance compared to both MDD and HC. In MDD, there is an observed amygdala volume increase compared to the HC. Additionally, correlation analysis revealed that the left amygdala volume is significantly correlated with Delayed Memory (List Recall) (r = 0.234, p = 0.010) and Delayed Memory (Story Recall) (r = 0.215, p = 0.018) (after multiple Bonferroni correction).
conclusionFor medication-naïve individuals with MDD and BD II, we observed a correlation between amygdala volume and cognitive function. From this, changes in amygdala volume may help reflect cognitive impairment in patients during the acute phase.
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