Evidence map›Paper›PMID 40877850›Full record

ArticleBMC neurology2025

APOE ε2 is associated with reduced risk of early post-stroke cognitive impairment but not with long-term functional outcome.

Yangbo Hou, Shuyun Hua, Zhi Guo, Jiwei Cheng, Guoyi Li, Liangqi Wang, Qian Xiao

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Article in BMC neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Yangbo Hou *Department of Neurology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200062, China.
Shuyun Hua *Department of Radiology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200062, China.
Zhi GuoDepartment of Radiology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200062, China.
Jiwei ChengDepartment of Neurology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200062, China.
Guoyi LiDepartment of Neurology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200062, China. iliguoyi@163.com.
Liangqi WangDepartment of Radiology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China. wang.liangqi@zsgmc.sh.cn.
Qian XiaoDepartment of Neurology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200062, China. emilyand208@126.com.

Funding

the Project for Capacity Promotion of Putuo District Clinical Special Disease 2023tszb04the Science and Technology Innovation Project of Putuo District Health System ptkwws202009
6 · The paper itself

Abstract

backgroundThe associations between APOE genotype and early cognitive impairment and long-term functional prognosis after acute ischemic stroke (AIS) are uncertain.

objectiveTo investigate the associations between APOE genotype and early cognitive impairment and long-term functional prognosis after AIS.

methodsOur study was a single-center, prospective cohort study, that included 109 patients with AIS. At baseline, APOE genotype, cognition and white matter hyperintensities (WMH) were assessed within 2 weeks of stroke onset. At 3 months and 18 months, the modified Rankin scale (mRS) was used to assess the functional outcome after stroke.

resultsε2 carriers had better cognitive performance than ε2 noncarriers did in the Montreal Cognitive Assessment (MoCA, p = 0.003) and the Trail Making Test (TMT, p = 0.038). Multivariate logistic regression analysis revealed that ε2 was an independent protective factor for early post-stroke cognitive impairment (OR 0.213, 95% CI 0.055–0.820), whereas ε4 was not associated with early post-stroke cognitive impairment (OR 2.582, 95% CI 0.314–21.219). ε2 had no significant effect on WMH, whereas ε4 aggravated WMH, especially in the deep white matter (DWM). No significant interaction effect between the Fazekas score and ε2 on early post-stroke cognitive impairment was found. Female sex (OR 7.081, 95% CI 2.531–19.813), admission NIHSS score (OR 1.265, 95% CI 1.062–1.507), and DWM Fazekas score (OR 2.224, 95% CI 1.106–4.469) were independent risk factors for long-term unfavorable prognosis after ischemic stroke.

conclusionε2 was associated with reduced risk of early post-stroke cognitive impairment, but not with the favorable long-term functional prognosis after stroke.

Indexed as

Apolipoprotein E2Cognitive DysfunctionIschemic StrokeStrokeAgedFemaleGenotypeHumansMalePrognosisProspective StudiesRecovery of FunctionApolipoprotein E2Apolipoproteins eCognitive dysfunctionGenotypeIschemic strokeLeukoaraiosisPrognosis

Identifiers

PMID40877850
PMCPMC12395658

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.