Evidence map›Paper›PMID 40877844›Full record

SynthesisBMC infectious diseases2025

Non-tuberculous mycobacterial infections among pulmonary tuberculosis suspected and confirmed patients in Ethiopia - A systematic review and meta analyses.

Deresse Daka, Belay Tessema, Awelani Mutshembele, Amir Alelign, Wubet Birhan, Baye Gelaw

RetractedAbstract readSystematic ReviewMeta-AnalysisRetracted Publication
In one paragraph

Synthesis in BMC infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Deresse DakaHawassa University college of Medicine and health sciences, Hawassa, Ethiopia. drsdk200@gmail.com.
Belay TessemaCollege of Medicine and Health sciences, Department of Medical Microbiology, Univeristy of Gondar, Gondar, Ethiopia.
Awelani MutshembeleSouth African Medical Research Council, South Africa Office of AIDS and TB, Pretoria, South Africa.
Amir AlelignCollege of Medicine and Health sciences, Department of Medical Microbiology, Univeristy of Gondar, Gondar, Ethiopia.
Wubet BirhanCollege of Medicine and Health sciences, Department of Medical Microbiology, Univeristy of Gondar, Gondar, Ethiopia.
Baye GelawCollege of Medicine and Health sciences, Department of Medical Microbiology, Univeristy of Gondar, Gondar, Ethiopia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionNontuberculous mycobacteria (NTM) are environmental pathogens found in soil, water, and various environments, causing chronic pulmonary infections. They are resistant to chlorine and extreme temperatures but not typically transmissible. NTM infections are often misdiagnosed as tuberculosis (TB), especially in Ethiopia, where data on prevalence is scarce. This research aims to analyze NTM isolation from pulmonary samples and other specimens used in pulmonary tuberculosis (PTB) diagnosis among patients suspected or confirmed as PTB cases in Ethiopia.

objectiveThis study systematically reviews and synthesizes published studies that report NTM isolation from sputum and other clinical samples in Ethiopia to estimate the overall prevalence of NTM isolation, identify the common species, and analyze regional variations in their occurrence.

methodsThis systematic review and meta-analysis aimed to determine NTM prevalence in infected individuals in Ethiopia. Using PubMed, Scopus, Web of Science, Google Scholar, and African Journals Online, we conducted a comprehensive literature search. Data extraction and quality assessment used the Newcastle-Ottawa Scale. Meta-analysis employed STATA-18 software with a random-effects model and included subgroup analysis. PROSPER registration: CRD420251000131.

resultsIn this review a total of 5,415 participants were involved and 53.8% were TB suspected patients, 37.6% were PTB patients, 4.0% were Multidrug resistance-tuberculosis (MDR-TB) patients, and 4.6% were Human Immunodeficiency virus (HIV) positive. The NTM prevalence was 3.8%, showing high heterogeneity and regional species variability. The meta-analysis highlighted differences in NTM prevalence across age groups and diagnostic tools, emphasizing the need for enhanced diagnostics and continuous surveillance to improve patient outcomes and inform public health strategies.

conclusionThe review summarizes the epidemiology and geographical distribution of NTM infections and common NTM species isolated among PTB suspected patients in Ethiopia, revealing regional variations and clinical implications. Despite limited data, Ethiopia has a lower prevalence of NTM compared to other African regions and the worldwide average.

Indexed as

Mycobacterium Infections, NontuberculousNontuberculous MycobacteriaTuberculosis, PulmonaryEthiopiaHumansPrevalenceSputumMeta-AnalysisNon-tuberculous mycobacteriaPulmonary tuberculosisSystematic review

Identifiers

PMID40877844
PMCPMC12392611

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.