Observational studyBMC anesthesiology2025
Decreased renal or cerebral oxygen saturation increases the risk of cardiac surgery-associated acute kidney injury in adult patients: a prospective observational study.
Observational study in BMC anesthesiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Mini-compendium on goal-directed perfusion (GDP) based on a narrative review.Journal of cardiothoracic surgery · 2026Review
- The Role of Biomarkers in Personalized Anesthesia: From Physiological Parameters to Molecular Diagnostics.Biomedicines · 2026Review
Corrections and comments
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Authors and funding
7 authors.
Funding
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Abstract
objectiveTo determine the relationship between intraoperative decreased renal and cerebral oxygen saturation, as measured using near-infrared spectroscopy (NIRS), and cardiac surgery-associated acute kidney injury (CSA-AKI) in adults.
methodsThis prospective observational study was conducted at Peking University International Hospital. Between November 2022 to August 2023, 101 adult patients undergoing cardiac surgery under cardiopulmonary bypass were included. Renal and cerebral tissue oxygen saturation was continuously monitored during the operation using NIRS.
resultsThe overall incidence of CSA-AKI was 27% (27/101), with a 4% incidence rate of requiring renal replacement therapy. The incidence of CSA-AKI was 57% (13/23) in patients with renal desaturation compared to 18% (14/78) in those without renal desaturation (P < 0.01). CSA-AKI occurred in 71% (12/17) of patients with cerebral desaturation compared to 18% (15/84) in those without cerebral desaturation (P < 0.01). The incidence of CSA-AKI was 100% (7/7) in patients with simultaneous renal and cerebral desaturation. Renal desaturation alone showed a sensitivity of 48%, while the combination of renal and cerebral desaturation demonstrated 100% specificity for predicting CSA-AKI.
conclusionsIn adult patients, 27% experience CSA-AKI. Intraoperative renal or cerebral desaturation, as monitored by NIRS, is associated with a higher risk of CSA-AKI, with simultaneous renal and cerebral desaturation which yielded the highest specificity in predicting postoperative AKI.
trial registrationThis study has been registered on the Chinese Clinical Trial Registry number (ChiCTR2200065161, 30/10/2022).
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