ArticleBMC pregnancy and childbirth2025
The diagnostic and prognostic value of APRI and de Ritis ratio in intrahepatic cholestasis of pregnancy.
Article in BMC pregnancy and childbirth, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- First-Trimester Hepatobiliary and Inflammatory Composite Indices as Candidate Markers for Subsequent Intrahepatic Cholestasis of Pregnancy: A Case-Control Study.Diagnostics (Basel, Switzerland) · 2026Article
- Association of albumin-based inflammatory indices with adverse neonatal outcomes in intrahepatic cholestasis of pregnancy: a retrospective comparative study.BMC pregnancy and childbirth · 2026Article
- Evaluation of Pulmonary Artery Acceleration/Ejection Time Ratio (PATET) and the AST-to-Platelet Ratio Index (APRI) in Intrahepatic Cholestasis of Pregnancy.Journal of clinical medicine · 2026Article
- Prediction of Pregnancy-Related Complications in Women of Advanced Maternal Age: A Nomogram Based on LASSO and Logistic Regression.International journal of women's health · 2026Article
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4 authors.
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Abstract
objectiveIntrahepatic cholestasis of pregnancy (ICP) is associated with adverse perinatal outcomes. Accurate and timely diagnosis is essential to minimize maternal and fetal risks. The standard diagnostic method-measurement of fasting serum bile acids (BA)-poses challenges due to limited availability, high cost, and delayed results. This study aimed to evaluate the diagnostic and prognostic utility of the aspartate aminotransferase to platelet ratio index (APRI) and the De Ritis ratio in ICP.
methodsThis retrospective case-control study included 238 pregnant women, categorized into three groups: mild ICP (n = 62), severe ICP (n = 57), and healthy controls (n = 119). Demographic, biochemical, and perinatal outcomes were compared among the groups. APRI and De Ritis ratios were calculated and analyzed using receiver operating characteristic (ROC) curves and correlation analyses.
resultsAPRI levels were significantly elevated in ICP patients and demonstrated strong diagnostic performance for identifying ICP (cut-off: 0.295; AUC = 0.842). The De Ritis ratio was significantly lower in both ICP groups compared with controls (cut-off: 1.097; AUC = 0.770). APRI also correlated with disease severity (cut-off: 0.615 for severe ICP; AUC = 0.868). Higher APRI values were associated with increased neonatal intensive care unit (NICU) admissions and lower gestational age and birth weight.
conclusionsAPRI and De Ritis ratios are simple, inexpensive, and non-invasive markers that may aid in the diagnosis and severity assessment of ICP. They could serve as useful alternatives in clinical settings where BA testing is limited or unavailable.
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