ArticleBMC cancer2025
Salvage involved-field versus extended-field chemoradiotherapy for postoperative lymph node metastasis in esophageal squamous cell carcinoma: a retrospective clinical study.
Article in BMC cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Treatment strategies for postoperative locoregional recurrent esophageal squamous cell carcinoma after curative resection: a narrative review.Esophagus : official journal of the Japan Esophageal Society · 2026Review
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Authors and funding
23 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEsophageal cancer is a major global health threat, causing over 187,000 deaths in China in 2022. Esophageal squamous cell carcinoma (ESCC) patients face high recurrence risks postradical esophagectomy, with 28.5% - 54% experiencing relapse. Current guidelines lack strong evidence for salvage treatments. Although salvage concurrent chemoradiotherapy has shown potential in improving outcomes, the optimal irradiation fields remain unclear. Therefore, this study aimed to compare salvage involved-field irradiation (IFI) versus extended-field irradiation (EFI) with concurrent chemoradiotherapy in postoperative thoracic ESCC patients with lymph node metastases, assessing whether IFI reduces toxicity without compromising efficacy.
methodsThis retrospective study included 106 patients (2015-2024) treated with IFI (targeting involved nodes) or EFI (involved nodes + prophylactic areas) plus concurrent chemotherapy. Outcomes included local control rate (LCR), disease-free survival (DFS), overall survival (OS), disease control rate (DCR), objective response rate (ORR), adverse events (CTCAE v5.0), and elective nodal control (ENC, IFI group).
resultsWith 57.2-month median follow-up, IFI and EFI showed comparable media OS (63.2 vs. 59.5 months, P = 0.519) and media DFS (28.4 vs. 17.8 months, P = 0.334). IFI achieved higher 3-/5-year LCR (81.1% vs. 61.8%; 60.8% vs. 49.4%, P = 0.026) and lower Grade 1-2 radiation esophagitis (29.3% vs. 46.9%), pneumonia (25.8% vs. 40.8%), and Grade 3-4 toxicity (32.8% vs. 57.1%, all P < 0.05). No significant differences in ORR/DCR were observed. IFI's ENC was 10.5% (6/57).
conclusionSalvage IFI demonstrates non-inferior efficacy to EFI with significantly reduced severe toxicity (32.8% vs. 57.1%, P = 0.011) and potential survival benefits in single-node metastases, supporting its clinical prioritization.
trial registrationThis retrospective study was approved by the Ethics Committee of Jiangsu Cancer Hospital (Ethical Approval No. [KY-2024-020]).
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