Trial reportBMC anesthesiology2025
Comparing the efficacy of combining ketorolac and Paracetamol (Acetaminophen) with Paracetamol alone on postoperative pain after laminectomy. A double-blinded randomized clinical trial.
Trial report in BMC anesthesiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Postoperative pain management: Comparison of intravenous paracetamol versus ketorolac.Bioinformation · 2025Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPostoperative pain management has driven a shift toward non-opioid analgesics. Combining Paracetamol (Acetaminophen) and Ketorolac, a multimodal analgesic approach shows potential. However, evidence on the synergistic effects of these combinations remains limited, particularly for laminectomy.
methodsThis randomized, double-blinded controlled trial was conducted between March 2023 and December 2024. Eligible patients were adults undergoing laminectomy who met the inclusion and exclusion criteria. Participants were randomized to receive either conventional Paracetamol (1000 mg) with or without Ketorolac (30 mg) every 6 h for 24 h. Primary outcomes included postoperative morphine consumption and pain intensity measured by the Visual Analogue Scale (VAS). Secondary outcomes included hemodynamic changes and the incidence of postoperative nausea and vomiting (PONV).
resultsA total of 90 patients completed the study, with comparable baseline demographics between groups. The intervention group required significantly less morphine (0.35 ± 0.95 mg) compared to the control group (1.33 ± 3.03 mg) in the first 24 h post-surgery (p = 0.02). Pain intensity decreased over time in both groups, with no significant differences observed in VAS scores. Hemodynamic parameters were more stable in the intervention group, with lower systolic and diastolic blood pressures over time; however, some results were not statistically significant. The incidence of PONV was similar between groups.
conclusionsWhile the combination therapy demonstrated trends toward improved hemodynamic stability, some parameters, such as DBP and MAP, did not reach statistical significance, warranting further exploration. Further research is recommended to validate the broader applicability of this combination in various surgical contexts.
trial registrationThe study was registered at irct.behdasht.gov.ir/trial/66,286 (IRCT20221010056140N1, registration date: 01/28/2023).
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