Observational studyBMC primary care2025
Capillary CRP in primary care in France: an observational study.
Observational study in BMC primary care, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAntibiotic resistance causes 700,000 deaths annually worldwide. In France, diagnostic uncertainty in consultations leads to inappropriate prescribing of antibiotics, which increases antibiotic resistance. Capillary C-reactive protein (CRP) machines can provide a CRP measurement in primary care in two minutes and can help general practitioners in their prescribing decisions. The aim of this study was to evaluate the use of capillary CRP in primary care, as well as its impact on the following: the main reasons for consultation, the influence of the results on antibiotic prescribing, and patient outcomes at eight days and three months.
methodsThis was a multicentre (four centres) cross-sectional observational study including all patients with capillary CRP measurements during primary care consultations from January 1, 2022, to March 1, 2023. Patients in centre 1 were called by phone at eight days and at three months after their consultation to evaluate their recovery (patient perception).
resultsDuring the study period, 91 capillary CRP measurements were performed on 90 patients. A CRP level ≥ 20 mg/L was statistically associated with antibiotic prescription (odds ratio: 12.0, 95% confidence interval: 1.91 to 75.8, p = 0.008). The 45 patients from centre 1 called by phone were cured of bacterial infections at three months, none were hospitalised, and 20.0% returned for another consultation.
conclusionsWhen the CRP concentration was < 20 mg/L, doctors prescribed fewer antibiotics. Antibiotic prescriptions appear to decrease in France with the use of capillary CRP.
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