ArticleSleep & breathing = Schlaf & Atmung2025
Quantification of electromyographic activity during REM sleep in Chinese narcolepsy patients and healthy controls: a comparative study.
Article in Sleep & breathing = Schlaf & Atmung, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- Rapid Eye Movement Sleep-Related Indicators with Promising Performance in Diagnosing Narcolepsy.Nature and science of sleep · 2026Article
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Authors and funding
7 authors.
Funding
Abstract
STUDY
objectivesThis study aimed to assess and quantify rapid eye movement (REM) sleep electromyographic (EMG) activity in narcolepsy patients.
methodsThe study involved 95 participants, including 25 with narcolepsy type 1 (NT1), 36 with narcolepsy type 2 (NT2), and 34 healthy controls (HC). We visually analyzed phasic, tonic, and "any" muscle activity for the submentalis (SM) and phasic for the anterior tibialis (AT) by both 3-s REM mini-epochs (3sRME) and 30-s REM epochs (30sRE) methods. Group metrics of EMG activity indices in 3sRME and positive REM sleep without atonia (RWA) indices in 30sRE (AASM rules) were analyzed. Receiver operating characteristic (ROC) curves determined the best cutoff thresholds for narcolepsy.
resultsAll median SM and AT EMG activity indices in 3sRME were significantly higher in NT1 and NT2 compared to HC (P < 0.05). In the 30sRE method, positive RWA with phasic SM, total SM, and combined SM + AT indices were significantly higher only in NT1 versus HC in all analyses. The 3sRME phasic AT index had the highest area under the curve (AUC) of 0.884 (cutoff > 1.74%) for narcolepsy, 0.920 (cutoff > 2.03%) for NT1, and 0.859 (cutoff > 1.74%) for NT2. In the 30sRE method, the positive RWA with combined SM + AT index had the highest AUC of 0.691 (cutoff > 4.37%) for narcolepsy.
conclusionsThe study demonstrated increased levels of REM sleep EMG activity in narcoleptic patients compared to HC, with more pronounced abnormalities in NT1 than NT2, suggesting its potential as an alternative biomarker for narcolepsy.
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