Evidence map›Paper›PMID 40877705›Full record

ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2025

Profiling of psychoneurological symptoms in newly diagnosed head and neck cancer patients.

Joan C Medina, Femke Jansen, Birgit I Lissenberg-Witte, Remco de Bree, Ruud H Brakenhoff, Jose Hardillo, Johannes A Langendijk, C René Leemans, Robert P Takes, Femke Lamers and 1 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Joan C MedinaDepartment of Psychology and Education Sciences, Universitat Oberta de Catalunya, Barcelona, Spain. jmedina1@uoc.edu.ORCID http://orcid.org/0000-0002-4550-2157
Femke JansenDepartment of Otolaryngology-Head and Neck Surgery, Amsterdam University Medical Center Location Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0002-0111-0557
Birgit I Lissenberg-WitteDepartment of Epidemiology and Data Science, Amsterdam University Medical Center Location Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0001-9448-1826
Remco de BreeDepartment of Head and Neck Surgical Oncology, University Medical Center Utrecht, Utrecht, The Netherlands.ORCID http://orcid.org/0000-0001-7128-5814
Ruud H BrakenhoffDepartment of Otolaryngology-Head and Neck Surgery, Amsterdam University Medical Center Location Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0003-3251-5378
Jose HardilloDepartment of Otorhinolaryngology, Erasmus MC Cancer Institute, University Medical Center, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0001-5580-5613
Johannes A LangendijkDepartment of Radiation Oncology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.ORCID http://orcid.org/0000-0003-1083-372X
C René LeemansDepartment of Otolaryngology-Head and Neck Surgery, Amsterdam University Medical Center Location Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0001-7887-083X
Robert P TakesDepartment of Otorhinolaryngology-Head and Neck Surgery, Radboud University Medical Center, Nijmegen, The Netherlands.ORCID http://orcid.org/0000-0003-4784-0499
Femke LamersDepartment of Psychiatry, Amsterdam University Medical Center Location Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0003-4344-5766
Irma M Verdonck-de LeeuwDepartment of Otolaryngology-Head and Neck Surgery, Amsterdam University Medical Center Location Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0002-4507-4607

Funding

Cancer Center Amsterdam Visiting professorship positionKWF Kankerbestrijding VU 2013-5930
6 · The paper itself

Abstract

purposeHe ad and neck cancer (HNC) can trigger a significant mental health burden, including psychoneurological symptoms (PNS). Better insight into the profiling of PNS is important for advancing personalized mental health screening and management.

methodsData from 538 newly diagnosed adult HNC patients participating in a prospective multicenter cohort study (NET-QUBIC) were used. Questionnaires were used to assess PNS. Sociodemographic, clinical, lifestyle, and biological variables were collected. Latent class analysis was performed to identify differential classes of PNS. Between-class comparisons and multivariable logistic regression analyses were conducted to characterize each profile in relation to sociodemographic, clinical, lifestyle, and biological variables.

resultsFit indexes supported a three-class solution, with patients distributed in mild (60%), moderate (26%), and severe (14%) PNS classes. Pain and sleep problems were featured in all classes, anxiety and depression in the moderate and severe classes, and fatigue only in the severe class. Patients in the moderate and severe classes were more often women, had oral cavity cancer, showed impaired performance, had a history of anxiety and depression disorders, were daily smokers, had higher CRP, and had a flatter cortisol slope compared to the mild class.

conclusionNewly diagnosed HNC patients can be classified according to the severity of PNS. Several sociodemographic, clinical, lifestyle, and biological variables are proposed as drivers for early detection and treatment of mental health burden.

Indexed as

Head and Neck NeoplasmsAdultAgedAnxietyCohort StudiesDepressionFatigueFemaleHumansLatent Class AnalysisLife StyleLogistic ModelsMaleMiddle AgedProspective StudiesSeverity of Illness IndexAnxietyDepressionInflammationLatent class analysisMental healthScreening

Identifiers

PMID40877705
PMCPMC12394295

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.