Evidence map›Paper›PMID 40877622›Full record

ArticleSurgical endoscopy2025

Innovative staining for endoscopic screening of early esophageal cancer and precancerous lesions: a preclinical study.

Yuan Gao, Jiachang Li, Xiaopeng Xu, Bin Yu, Shishuai Xiang, Long He, Yuhang Zhang, Jia Xie, Jiang Du, Bing Hu

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Article in Surgical endoscopy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Yuan Gao *Department of Gastroenterology and Hepatology, Digestive Endoscopy Medical Engineering Research Laboratory, West China Hospital, Med-X Center for Materials, Sichuan University, Chengdu, 610041, People's Republic of China.
Jiachang Li *Department of Cardiovascular Surgery, Institute of Cardiovascular Surgery, West China Hospital, Sichuan University, Chengdu, 610041, People's Republic of China.
Xiaopeng XuSchool of Chemical Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu, 610065, People's Republic of China.
Bin YuInstitute for Disaster Management and Reconstruction, Sichuan University-The Hong Kong Polytechnic University, Chengdu, 610200, People's Republic of China.
Shishuai XiangDepartment of Chemistry, College of Chemistry and Engineering, Xiamen University, 422 South Siming Road, Xiamen, Fujian, 361005, People's Republic of China.
Long HeDepartment of Pancreatic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People's Republic of China.
Yuhang ZhangDepartment of Gastroenterology and Hepatology, Digestive Endoscopy Medical Engineering Research Laboratory, West China Hospital, Med-X Center for Materials, Sichuan University, Chengdu, 610041, People's Republic of China.
Jia XieDepartment of Gastroenterology and Hepatology, Digestive Endoscopy Medical Engineering Research Laboratory, West China Hospital, Med-X Center for Materials, Sichuan University, Chengdu, 610041, People's Republic of China.
Jiang DuDepartment of Gastroenterology and Hepatology, Digestive Endoscopy Medical Engineering Research Laboratory, West China Hospital, Med-X Center for Materials, Sichuan University, Chengdu, 610041, People's Republic of China.
Bing HuDepartment of Gastroenterology and Hepatology, Digestive Endoscopy Medical Engineering Research Laboratory, West China Hospital, Med-X Center for Materials, Sichuan University, Chengdu, 610041, People's Republic of China. hubing@wchscu.edu.cn.ORCID http://orcid.org/0009-0007-2272-747X

Funding

Med-X Innovation Programme of Med-X Center for Materials, Sichuan University MCM202302
6 · The paper itself

Abstract

backgroundLugol's iodine staining (LIS) solution is used to assist in esophageal chromoendoscopy. Mucosal irritation often results in uncomfortable symptoms and the risk of allergy. In the present study, we developed an extremely low-irritation, easy-to-use mucosal staining solution using polyvinyl pyrrolidone-iodine (PVP-I). This study aimed to evaluate its mucosal staining capacity and biocompatibility.

methodsThe mucosal staining capacity was evaluated using postoperative esophageal endoscopic submucosal dissection (ESD) specimens. After elution with vitamin C solution, the specimens were sprayed with LIS as a self-control. The effects on the "lesion area" outlined between the innovative staining and LIS were examined by the intraclass correlation coefficient (ICC) and rank-sum test. To evaluate the biocompatibility, esophageal perfusion was performed with the mice, and the esophagus and stomach were anatomized at different time points for pathological analysis.

resultsA total of 53 esophageal ESD specimens were stained at the endoscopy center of West China Hospital. Compared with the same concentration of LIS, the PVP-I solutions showed similar staining effects in terms of the lesion area outlined [ICC = 0.998 (> 0.75), P = 0.733 (> 0.05)]. In live mouse experiments with esophageal perfusion, PVP-I was safer and less irritable to the esophageal gastric mucosa than LIS was, with a lower mucosal damage index (UI) and fewer inflammatory cells in pathological analysis at various time points.

conclusionsThe innovative PVP-I staining demonstrated effectiveness, safety, and feasibility as a mucosal staining solution for screening esophageal lesions. Further clinical studies will be carried out in the future.

Indexed as

Early Detection of CancerEsophageal NeoplasmsEsophagoscopyIodidesPrecancerous ConditionsStaining and LabelingAnimalsColoring AgentsEndoscopic Mucosal ResectionEsophageal MucosaFemaleHumansMaleMiceMiddle AgedPovidoneColoring AgentsIodidesLugol's solutionPovidoneEsophageal neoplasmsPrecancerous conditionsStaining and labeling

Identifiers

PMID40877622

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.