SynthesisLangenbeck's archives of surgery2025
Efficacy of tranexamic acid in reducing perioperative blood transfusions and thrombosis in liver surgery: a systematic review and meta-analysis.
Synthesis in Langenbeck's archives of surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
introductionPreventing bleeding during the perioperative period is critically important in liver surgery and mismanagement can raise the need for transfusions as well as the rates of morbidity and death. Tranexamic acid (TXA) has been shown to effectively decrease perioperative bleeding in patients with trauma, some studies have also shown that TXA plays the same role in liver surgery. The effectiveness of TXA in hepatectomy and liver transplantation was reassessed in this meta-analysis of randomized controlled trials, which included recently published studies.
methodsThe PubMed, Web of Science, and Embase databases were comprehensively searched to identify studies that were published from January 1947 to September 2024. Results related to transfusion requirements, incidents of thromboembolism, and the number of deaths were retrieved from the included studies. The data were quantified using random effects models.
resultsA total of 1674 patients were included in the seven studies. The results showed no discernible difference between the TXA and control groups regarding the reduction in perioperative transfusion needs (OR 0.24; 95% CI 0.03 ~ 1.87) and the final mortality rate (OR 0.99; 95% CI 0.48 ~ 2.06) during hepatectomy and transplantation, however, TXA increased the incidence of thromboembolism (OR 1.74; 95% CI 1.01 ~ 3.01).
conclusionsTXA does not reduce perioperative transfusion requirements during liver resection and transplantation and has no significant effect on the final mortality rate; however, TXA does increase the incidence of thromboembolic events.
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