ArticleNPJ digital medicine2025
Emphysema progression risk in COPD using a localized foundational model of density evolution.
Article in NPJ digital medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed.
- Cooperation, Defection, and Collapse: A Multiscale Game Theory Framework for Emphysema Progression.Cells · 2026Review
- A self-supervised framework for emphysema anomaly detection and staging in computed tomography scans.Patterns (New York, N.Y.) · 2026Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Emphysema progression in chronic obstructive pulmonary disease (COPD) presents a notable challenge due to its significant variability among individuals and the current lack of reliable prognostic markers. Given the limited therapeutic options available for emphysema, there is a critical need for early detection and intervention strategies. Identifying individuals at risk of rapid progression is essential to effectively halt or slow the disease's advancement. This study introduces an innovative approach employing a localized foundational model of density evolution to pinpoint local radiographic embeddings indicative of emphysema progression. Central to our methodology is the Local Emphysema Progression (LEP) score, a novel metric derived from our model that aggregates localized lung tissue activations into a comprehensive, subject-level risk assessment tool. The model's performance was tested on 3728 COPDGene participants, comparing baseline to 5-year, and 1421 scans taken from the 5-year to 10-year interval period. Additionally, our findings were replicated in 1058 ECLIPSE participants. The model effectively identifies lung regions with emphysema progression, achieving an AUC of 0.88. The LEP risk score shows good correlation with the change in the percentage of low attenuation areas below -950 Hounsfield Units (Δ%LAA-950), with correlation values of 0.50 in the COPDGene cohort and 0.40 in the ECLIPSE cohort among subjects with emphysema progression (Δ%LAA-950 > 0). Furthermore, LEP risk score associates with mortality and several COPD outcomes, underscoring its potential as a valuable tool in clinical prognosis and management of emphysema progression in COPD patients.
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Registered trials
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